Welcome to Catalyst University! I am Kevin Tokoph, PT, DPT, and this is one of my earlier biochemistry videos where we discuss the function of pyruvate dehydrogenase, the intermediate step between glycolysis and the citric acid cycle.
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@rafik172839
6 years ago
Hi Kevin! thx for a great vid on pyruvate dehydrogenase reaction! I have a couple of question, I'm asking for a patience in advance, hope they aren't too silly to ask... 1) 3:47 you are saying that ''enzyme deprotonate that carbon'' ... I'm curious whether this is a spontaneous action taking place in mitochondrial matrix on a regular basis?? 2) 4:27 here you say ''...and this bond is gonna come out and abstract a proton.'' I totally understand that rearrangemnts of electrons density leads to the loss of one bond, because we know that carbon is always 4-bonded... but I don't get the concept of transformation of covalent bond into a proton... isn't a covalent bond created when two atoms equally share a pair of electrons? where have they been ''lost'' in this case? UPDATE : I probably understood how it is meant - please, correct me if I am wrong - the orientation of arrows probably confused me - it is that electrons from a pi bond are used to make a new simple sigma bond with that proton from environment? Thank you very much!
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