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3,289,503 Views ā¢ Dec 27, 2021 ā¢ Click to toggle off description
In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.
#HubermanLab #DavidSinclair #Longevity
Thank you to our sponsors:
ROKA - www.roka.com/huberman
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Magic Spoon - www.magicspoon.com/huberman
Dr. David Sinclair Links:
Lifespan Podcast: lifespanpodcast.com/
Twitter: twitter.com/davidasinclair
Instagram: www.instagram.com/davidsinclairphd/
YouTube: youtube.com/davidsinclairpodcast
Lifespan (book): amzn.to/47MLimC
Aging Test Waitlist: www.tallyhealth.com/
Harvard Lab Website: sinclair.hms.harvard.edu/
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www.patreon.com/andrewhuberman
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www.thorne.com/u/huberman
Social:
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Twitter - twitter.com/hubermanlab
Facebook - www.facebook.com/hubermanlab
Website - hubermanlab.com/
Newsletter - hubermanlab.com/neural-network
Timestamps:
00:00:00 Dr. David Sinclair, Harvard Medical School
00:03:30 ROKA, InsideTracker, Magic Spoon
00:07:45 āAging as a Diseaseā vs. Longevity & Anti-Aging
00:10:23 What Causes Aging? The Epigenome
00:15:53 Cosmetic Aging
00:17:15 Development Never Stops, Horvath Clock
00:20:12 Puberty Rate as a Determinant of Aging Rate
00:23:00 Fasting, Hunger & Food Choices
00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy
00:34:50 Caffeine, Electrolytes
00:35:56 Blood Glucose & the Sirtuins; mTOR
00:37:55 Amino Acids: Leucine, āPulsingā
00:44:35 Metformin, Berberine
00:50:29 Resveratrol, Wine
00:53:20 What Breaks a Fast?
00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing
01:09:10 Are Artificial Sweeteners Bad for Us?
01:12:04 Iron Load & Aging
01:15:05 Blood Work Analysis
01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary
01:26:02 Amino Acids, Plants, Antioxidants
01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen
01:40:35 Neuroplasticity & Neural Repair
01:46:19 Ice Baths, Cold Showers, āMetabolic Winterā
01:48:07 Obesity & How It Accelerates Aging, GnRH
01:52:10 Methylation, Methylene Blue, Cigarettes
01:56:17 X-Rays
01:59:00 Public Science Education, Personal Health
02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com
02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram
The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the userās own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com/
Audio Engineering: Joel Hatstat at High Jump Media
Views : 3,289,503
Genre: Science & Technology
Date of upload: Dec 27, 2021 ^^
Rating : 4.94 (1,166/76,220 LTDR)
RYD date created : 2022-04-09T17:50:30.69385Z
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YouTube Comments - 4,872 Comments
Top Comments of this video!! :3
Welcome to the Future everyone, where golden information like this is free and available instantly.
2.1K |
My father is 97 years old. He is a WWII vet and has survived double pneumonia, sepsis and Covid in the last two years. And he rides his recumbent bicycle 30 minutes daily. His longevity, in my opinion, is directly related to his low caloric intake (and great caretaking). Heās eaten once or twice per day for his entire life. Super interesting science. Thank you.
1.9K |
Dr. Huberman is really creating an amazing legacy of information. The only problem I have with him is that I get lost in those eyes and forget to listen.
80 |
Why I love Dr. Sinclair. He always answers so honestly. āWe donāt know, but Iāll give you my best answer.ā I appreciate you both for taking the time to educate us!
91 |
Two scientists that I follow all the time, now on one podcast. This is a Christmas gift.
1.7K |
I am a practicing physician assistant and went into medicine because my family has always been on the wholistic/ natural path. We grew our own veggies, bought farm fresh eggs and grass fed local beef, had fruit trees and grape arbors. We ate fruits and veggies all day. We were physically active all day. My father is 93 and not on any meds. My mom is 89. They do not smoke and rarely drink alcohol. They have never had cancer, diabetes, dementia, heart disease. I have been telling patients for years that it is not rocket science and the best treatment I can give them is to eat only to live and keep moving. I could talk for hours about this! Our food production and lifestyles are killing us. It is that simple!! I would love to help get more of this information out there! And I would love to meet you both! Thank you and Keep up the great work!
444 |
Menopause is brutal. It led me to David Sinclair and life changes... i feel so much better but still not the same as before. We desperately need more research to address this bro real issue affecting over half the population.
13 |
This is going to sound backwards but seeing this makes me grateful for that anorexia diagnosis in high school. Iām saying this on the other end of it, as a middle-ish aged woman, and forever grateful that I survived and recovered, but glad to know that there was likely a silver lining to that hell.
1 |
Imagine how the internet has changed the world. You can now easily prolong your life for free because of technology and intelligent people like Andrew
781 |
In addition to the generosity and vast knowledge provided, can we all agree that this podcast is most enjoyable due to the fact that these two gentlemen utilize the art of conversation very well? No interrupting, grandstanding, one upmanship, talking over one another. A lost art, indeed. Well-directed by Dr .Huberman and cooperative responses by Dr. Sinclair. Riveting!! Thank you both!
294 |
I felt like I was sitting in on a lecture and I was engaged the whole time! Super informative and insightful! Thank you so much!
22 |
I have to say that the obvious enthusiasm and excitement you both show as you discuss these topics is absolutely wonderful.
7 |
One thing I question is the exposure to cold. I was homeless for 6 years and it wrecked my health. I have to say right here that I don't do drugs, that was never my problem, because a lot of people on the streets self-medicate, but I never liked drugs, not even pot. The main contributing factors for my health deterioration were were chronic stress (bordering on PTSD), especially due to constant police and societal harassment, and poor diet, due to being poor, eating old, cold and cheap foods. However, one other thing started really messing my hormones up, and that was living through winters and snow without heating. I lived in my van, so I would get under the feather comforter and sleeping bag at night and shiver for about an hour until my own body heat would heat up the space. I was able to get warm during the days at a cafe or library, but there was no refuge at night from the cold. The last couple winters, my body started having trouble self-regulating its heat. I would be so cold, and then I would suddenly overheat and be sweating. I have gone into early menopause in my early 40's. I am totally traumatized by the cold now. I feel like Scarlet O'Hara in "Gone With the Wind," except I would say, "As God is my witness, I will never go cold again!" Dr. Sinclair saying he wears a T-shirt in winter gives me shivers. So I respect deprivation of our ancestors (and the current indigent) as something that can be absolutely damaging. The homeless have a much lower lifespan than the rest of society. Controlled deprivation is still privileged deprivation. That being said, we do live in a society of sickening over-abundance. And I do notice that wealthier people often seem less happy than the homeless, where the smallest thing is appreciated. I watched your video on dopamine, and it finally made sense to me why that is. Now that I am housed, I am able to rest and heal and have some peace, but I'm also in a slump. Being alive in this world is a difficult balance between security and thrill.
653 |
Iām 35 now and starting to see and feel it. I swear I was 22 just yesterday. Time flies!
81 |
Currently watching this. Only recently discovered Dr David Sincalir and Huberman this morning. An absolute pleasure to listen to these 2 gentlemen. I'm defo going down this rabbit hole lol
5 |
When I first listened to this podcast, it was about one year ago. Since then, I had listened to many other similar podcasts. I learned so much from all of them. This time listening to this one, I understood the subject so much better.
3 |
I just turned 60 and am the caregiver for my mom who this week turns 100!!!! For her age she is doing amazingly well. As I see her quality of health, it spurs me on to increase my health span not just my life span.
82 |
I knew it was only a matter of time until Dr David Sinclair made his way onto your show. Thank you Andrew!
316 |
Dear Andrew,
I want to give you a huge shoutout and express my gratitude for all the awesome info you're putting out there hosting such great minds and the incredible work you're doing to make education accessible. On top of all the cool science stuff, your subtle sense of humor really adds to the experience. Watching your videos is a blast! Thanks a ton!
8 |
@hubermanlab
2 years ago
The first episode of Dr. David Sinclair's new podcast launches Wednesday, January 5, 2022. You can subscribe now to that podcast, "Lifespan with Dr. David Sinclair", on all podcast platforms ( lifespanpodcast.com/ ) and here on YouTube: youtube.com/davidsinclairpodcast. Thank you for your interest in science!
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