Views : 374,726
Genre: Science & Technology
Date of upload: Aug 25, 2023 ^^
Rating : 4.894 (279/10,282 LTDR)
RYD date created : 2024-05-13T17:40:35.720435Z
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Top Comments of this video!! :3
As a scientist and specifically a structural biologist (I study protein and RNA structures) I was amazed at Cleo mentioning AlphaFold! To drive medicine forward, you really have to understand what shape and sizes proteins take and how can we, as scientist, could design potential medications that target these proteins to prevent them from working or maybe even improve some proteins function.
For decades, there have been 3 structural techniques that can solve protein and RNA structures - 1) Nuclear Magnetic resonance, 2) X-Ray crystallography, and 3) Cryo-EM and all three have their differences pros and cons. But now AlphaFold can predict 3D protein structures without having to solve a structure with one of the 3 techniques and it is especially good by looking at single domain proteins - a segment that can fold independently while AlphaFold has more difficulty with multi domain proteins - one segment folding affects another segment. The next future steps will be how can AI predict RNA structures and more complex structures like RNA binding to proteins.
Hope this helps clarify some of the points but loved to see biomedical science being discussed in the podcast!
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@Drewbert__
8 months ago
Cleo Abram: “How do we smash atoms together and why?” Waveform podcast: “So uh… how does a boat work?” The duality of man.
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