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Studies
sci-hub.se/10.3109/00365521.2013.863963
sci-hub.se/10.1016/j.clinre.2022.101954
sciencedirect.com/science/article/pii/S17564646210…
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This water consumed for a year improved a TON of metrics.
Metabolic:
◆ AST: ↓ 11.7%
◆ ALT: ↓ 31.3%
◆ GGT: ↓ 33.3%
◆ Hs-CRP: ↓ 28.4%
◆ HDL: ↑ 26.7%
◆ LDL: ↓ 26.6%
◆ Insulin: ↓ 33.7%
◆ CAP (liver fat): ↓ 4.8%
Gut permeability:
◆ Fecal zonulin: ↓ 17.7%
◆ Serum occludin: ↑ 16.7%
◆ Serum claudin-1: ↑ 39.6%
◆ LPB: ↓ 15.1%
◆ Serum LPS: ↓ 65.5%
Inflammation:
◆ IL-1β: ↓ 17.3%
◆ IL-6: ↓ 23.8%
◆ TNF-α: ↓ 17.7%
Antioxidant:
◆ Free radical production (dROMs): ↓ 47.2%
◆ Biological Antioxidant Potential (BAP): ↑ 10.7%
◆ dROMs/BAP ratio: ↓ 55.2%
PMID: 41228524
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Weight loss tanks metabolism + thyroid hormones - leptin restores them.
Giving people leptin:
➤ Boosts energy expenditure
➤ Increases thyroid hormones T3 and T4
Back to normal levels after weight loss.
Increasing leptin is THE KEY to successful long term weight loss.
We need to look at how leptin works to do this.
In the hypothalamus of the brain, leptin (and insulin) act on brain cells, which produce a compound called αMSH.
αMSH then acts on other neurons to:
◇ Decrease inappropriate appetite
◇ Make the fat “brown,” which increases its heat production and metabolism
◇ Increases thyroid hormones, which increase whole body metabolism
αMSH is melanocyte stimulating hormone, because it also acts on cells that produce melanin, which is what makes your skin and hair darker.
This all works like a charm, but both inflammation and oxidative stress cause the hypothalamus to become unresponsive to leptin.
In other words, you’re fat because you basically have a microscopic headache.
Whether the issue is a lack of leptin or a lack of response to it - ultimately the result is the same: you eat more and have a worse metabolism, keeping you fat or regaining weight.
PMID: 10546697
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Full study here: www.frontiersin.org/journals/cardiovascular-medici…
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62 - 4
And they told you it’s just for headaches.
68 - 3
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102 - 6
Exhaustive endurance exercise can lead to infertility and hormonal disruptions, but adding in 70g of raw honey increases:
◎ Semen volume
◎ Sperm morphology
◎ Sperm motility
◎ Antioxidant enzymes (SOD, Catalase)
◎ Total antioxidant capacity
while reducing every inflammatory marker measured.
PMID: 21636735
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Joined 19 July 2019