Virginia’s Commonwealth Cyber Initiative (CCI) is a state-wide ecosystem of innovation and excellence in cyberphysical systems with an emphasis on trust and security. Through a multimillion dollar investment from the Commonwealth of Virginia, the initiative seeks to ensure Virginia is recognized as a global leader in secure cyberphysical systems and the digital economy for decades to come by supporting world-class research at the intersection of data, autonomy, and security; promoting technology commercialization and entrepreneurship; and preparing future generations of innovators and research leaders. CCI is a highly connected network that engages institutions of higher education, industry, government, and non-governmental and economic development organizations. The network is composed of four CCI Regional Nodes, encompassing Central Virginia, Coastal Virginia, Northern Virginia, and Southwest Virginia; the hub is located in the Virginia Tech Research Center in Arlington, Virginia.