Hi HyGuru fam. Can you guess the answer to this NBME question? Please put your answer in the comments.
12 - 13
The 3️⃣ causes of Cherry Red Macula you need to know for the USMLE 🍒…
Tay-Sachs Disease 🧬
↓ Hexosaminidase A → ↑ GM2 ganglioside accumulation
Key: developmental regression, hyperacusis, cherry-red macula WITHOUT hepatosplenomegaly
💡 Pro tip: typically, the USMLE will say ‘normal abdominal exam’ in the vignette.
Additionally, many NBME questions talk about → frameshift mutation as a cause of Tay-Sachs!
Niemann-Pick Disease 🔬
↓ Sphingomyelinase → ↑ sphingomyelin in macrophages
Key: neurodegeneration, foam cells, cherry-red macula WITH hepatosplenomegaly
Central Retinal Artery Occlusion (CRAO) 🚨
↓ Retinal blood flow → acute ischemia
Key: sudden painless vision loss, pale retina with cherry-red macula, boxcarring of vessels
#medstudent #medschool #medicalschool #medicalstudent #usmle #usmlestep1 #step1 #usmlestep2
82 - 0
Hi HyGuru fam, here are the answers to yesterday's poll...
43 - 1
So guys, before my upcoming USMLE review on Fungi & Parasites this weekend, I’d thought it would be helpful to isolate the top Fungi & Parasites that show up 𝘳𝘦𝘱𝘦𝘢𝘵𝘦𝘥𝘭𝘺 on NBME exams.
Here’s the rapid review:
Cryptococcus 🧠
Immunocompromised meningitis → India ink. CSF: ↑protein, ↓glucose, ↑lymphocytes.
Mucor/Rhizopus 👃
DKA red flag → black necrotic nasal eschar. Think rapid angioinvasion.
Aspergillus 🫁
Recurrent asthma/ABPA clues → “fungal balls,” catalase positive.
Trypanosoma cruzi ❤️
South America → Chagas. Ventricular aneurysm + achalasia pattern.
Lock in these & the rest of the fungi/parasites relevant for Step 1 this Saturday (11/8) at 10 AM EST via Zoom 💻. I’ll be organizing these via Organ Systems with tons of vignettes!
🔗 to register: us02web.zoom.us/webinar/register/WN_dZ-G2Q6DTly0Y-…
Space is limited!
#usmle #medstudent #medschool #usmlestep1 #step2ck #hyguru
51 - 0
A 46-year old presents with a 5-day history of rash. Exam shows a diffuse maculopapular rash across his trunk. He denies new soaps or travel. Vitals are normal.
Urine analysis:
WBCs - 50/hpf
Leukocyte esterase - negative
Nitrites - negative
Protein - 1+
What is the most likely diagnosis?
14 - 5
❗️Type IIa – Familial Hypercholesterolemia (FH) is the most high yield hereditary dyslipidemia for Step 1.
In UWorld, there’s a question where you have to know that there’s a defect in the LDL receptor and that leads to elevated blood LDL! 🩸
Remember, Type IIA is an autosomal dominant condition where there's a defect in the LDL receptor or ApoB-100, leading to elevated LDL with normal triglycerides.
If you have elevated LDL in the peripheral blood → atherosclerosis! 🔥
On the USMLE, you will see tendon xanthomas on the Achilles tendon, corneal arcus, and patients often develop premature coronary artery disease.
Hope this helps in your prep 💡
watch video on watch page
3 - 0
at times can seem low yield, but the NBME can hit you up with an ⬆️ ⬇️ outta no where!
tl;dr → Bartter has high urine Ca²⁺
90 - 1
Hi HyGuru fam. Please put your response to this high yield NBME question in the comments.
27 - 15
Sketchy Micro is an awesome resource for your first pass of learning USMLE microbiology. 🧫
However, there are very few resources that actually show you how to integrate and apply the knowledge after you accrue it!
That is exactly my goal on this Saturday 📆
We'll be going through the fungi and parasites that are tested repeatedly on NBME exam.
I'm going to be incorporating only the high-yield ones, and organized them by organ system! 🫀
I hope you can join me!
It's a Zoom link only for the first 100 students, so if you are going to register, out of respect for all, kindly do attend!
🔗 to register: us02web.zoom.us/webinar/register/WN_dZ-G2Q6DTly0Y-…
Saturday, November 8 at 10 AM EST
25 - 1
If you’re applying for the MATCH, and on the Residency interview grind, be ready for this line—“What questions do you have for me?” 📌
In general there are two interview formats to prep for your Residency interview:
1. Faculty-led: Interviewer has read your application and asks you questions surrounding the field & your motivations for the program.
2. Candidate-led: you drive it with thoughtful, open-ended questions (this one is challenging because you have to ask questions for 25+ min!) 😬
Mentally prepare for both.
All in all, be open ended and genuine with the questions which you ask faculty!
Drop which question you typically ask Faculty! 🫳🏽
#interview #residency #usmle #medstudent #medschool #interviewtips
watch video on watch page
2 - 0
Practicing Pediatric Critical Care physician with a Master's in Medical Education passionate about inspiring medical students to apply & integrate concepts for the USMLE Step 1 & Shelf/Step 2 CK exams.
I focus on integrating material, test taking strategies, active recall, and most importantly, making learning not just about the exam but for future patients!
Joined 5 November 2006