The Mid-Columbia River Fishery Resource Office is located in Leavenworth, Washington on the grounds of the Leavenworth National Fish Hatchery. A sub office is located in Yakima, Washington. The Mid-Columbia River Fishery Resource Office has been part of the Leavenworth Fisheries Complex since 2010. The Complex also includes the Leavenworth, Entiat, and Winthrop National Fish Hatcheries.
The office meets U.S. Fish and Wildlife Service goals and responsibilities in the Columbia River basin from the Yakima River in the south to the Canadian border including the Yakima, Wenatchee, Entiat, Chelan, Methow, and Okanogan basins.