- ZYNRELEF is indicated in adults for instillation to produce postsurgical analgesia for up to 72 hours after soft tissue and orthopedic procedures including foot and ankle, and other procedures in which direct exposure to articular cartilage is avoided.
- Limitations of Use: Safety and efficacy have not been established in highly vascular surgeries, such as intrathoracic, large 4 or more level spinal, and head and neck procedures.
- ZYNRELEF can increase the risk of serious cardiovascular and gastrointestinal events. Please see full Prescribing Information (including Boxed Warning and contraindications) and Important Safety Information at: zynrelef.com/prescribing-information.pdf.