The Department of Biological Engineering was founded in 1998 as a new MIT academic unit, with the mission of defining and establishing a new discipline fusing molecular life sciences with engineering. The goal of this biological engineering discipline is to advance fundamental understanding of how biological systems operate and to develop effective biology-based technologies for applications across a wide spectrum of societal needs including breakthroughs in diagnosis, treatment, and prevention of disease, in design of novel materials, devices, and processes, and in enhancing environmental health. Our departmental epigram is 'Creating Biological Technologies, from Discovery to Design', designating our intertwined emphases on advances in basic bioscience and in applied biotechnology.