Sangi Co., Ltd. in Japan, established in 1974, is a developer and marketer of oral care and health related products containing the calcium phosphate compound hydroxyapatite, the main component of teeth and bone. Using the same substance as the teeth to restore tooth enamel as early as 1980, Sangi developed the world's first remineralizing toothpaste (over 150 million tubes sold), chiefly under the 'APAGARD'® and 'APADENT'® brands. Sangi's proprietary ingredient, nano Medical Hydroxyapatite (nano<mHAP ®>) is approved as an anticaries agent in Japan.