https://www.sciencealert.com/finally-scientists-think-they-know-how-lithium-treats-bipolar-disorder
As Snyder explains: "Lithium has been used to treat bipolar disorder for generations, but up until now, our lack of knowledge about why the therapy does or does not work for a particular patient led to unnecessary dosing and delayed finding an effective treatment. Further, its side effects are intolerable for many patients, limiting its use and

https://www.webmd.com/bipolar-disorder/bipolar-disorder-lithium
Common side effects of lithium can include: Hand tremor (If tremors are particularly bothersome, dosages can sometimes be reduced, or an additional medication can help.) Increased thirst

https://www.healthline.com/health/bipolar-disorder/lithium-use-bipolar
Lithium treats the manic episodes of bipolar I disorder, which is the more severe of the two types of this disorder. It helps decrease the intensity of manic episodes. It also makes depressive

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484534/
Mode of action of lithium in bipolar disorder. Li is a monovalent (Li +) alkali metal and is widely used for the treatment of BD [].This alkali metal has been used for almost 60 years for BD as the "gold standard" [] for mood stabilization [].The pathogenesis of BD is complex [].Patients with bipolar affective disorder have reduced γ-aminobutyric acid (GABA) neurotransmission, which

https://www.psychologytoday.com/us/blog/psychiatry-history/202002/how-lithium-became-treatment-bipolar-disorder
Indeed, it came about while searching for a treatment for "brain gout," a non-existent disease. Because the history of lithium is so deeply interconnected with gout, let's take a moment to talk

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800957/
Lithium has been and continues to be the mainstay of bipolar disorder (BD) pharmacotherapy for acute mood episodes, switch prevention, prophylactic treatment, and suicide prevention. Lithium is also the definitive proof-of-concept agent in BD, although it has recently been studied in other psychoses as well as diverse neurodegenerative disorders.

https://news.mit.edu/2016/new-clue-how-lithium-works-brain-bipolar-0707
MIT biologists have discovered a possible explanation for why lithium helps patients with bipolar disorder. In a study of C. elegans worms, the researchers identified a protein, known as BPNT1, which is inhibited by lithium, making the worms less active.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125816/
What we know. Lithium is effective for prevention of recurrences of BD and reduces the risk of suicide. The response to prophylactic treatment runs in families. Most patients need plasma levels between 0.6 and 1.0mmol/L for a full clinical effect. Lithium works best in patients with classical (typical) features of BD.

https://annals-general-psychiatry.biomedcentral.com/articles/10.1186/s12991-023-00481-y
Background Bipolar disorder is one of the most burdensome severe mental disorders, characterized by high levels of personal and social disability. Patients often need an integrated pharmacological and non-pharmacological approach. Lithium is one of the most effective treatments available not only in psychiatry, but in the whole medicine, and its clinical efficacy is superior to that of other

https://www.uptodate.com/contents/bipolar-disorder-in-adults-and-lithium-pharmacology-administration-and-management-of-adverse-effects
INTRODUCTION. The efficacy of lithium for treating mania was discovered in 1949, making it the first medication specifically developed to treat bipolar disorder [].Lithium remains a mainstay of treatment for bipolar disorder, especially for acute mania and maintenance treatment [].In addition, lithium appears to reduce the risk of suicide in patients with bipolar disorder [], and may possibly

https://www.medicalnewstoday.com/articles/lithium
Lithium is a common treatment for bipolar disorder. It can reduce the symptoms of mania and hypomania, which may include: a feeling of elation. energized behavior. an elevated, expansive, or

https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Lithium/
What Is Lithium And What Does It Treat? Lithium is a mood stabilizer medication that works in the brain. It is approved for the treatment of bipolar disorder (also known as manic depression). Bipolar disorder involves episodes of depression and/or mania. Symptoms of depression include: Depressed mood - feeling sad, empty, or tearful

https://my.clevelandclinic.org/research/neurological/behavioral-health/bipolar-disorders-mechanism-of-lithium-treatment
Overview. Lithium is one of the most specific and effective treatments for bipolar disorder (BD) yet its mechanism of action remains unclear. This has impeded methods to monitor its effects and the development of new medications with similar efficacy and specificity. Our research focuses on understanding clinical efficacy of lithium in bipolar

https://www.medicalnewstoday.com/articles/240644
The most effective long-term treatment for bipolar disorder is lithium. It offers protection against depression and mania and reduces the risk of suicide and short-term mortality.

https://pubmed.ncbi.nlm.nih.gov/23371914/
Abstract. Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.

https://www.nhs.uk/medicines/lithium/
Lithium Brand names: Priadel, Camcolit, Liskonum, Li-Liquid. Find out how lithium treats mood disorders such as mania and bipolar disorder, and how to take it. NHS medicines information on lithium - what it's used for, side effects, dosage and who can take it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537229/
Introduction. Bipolar disorder (BD) is a chronic psychiatric disorder characterized by fluctuations in mood state within recurrent episodes of mania, hypomania, and depression [].It occurs in approximately 2% of the global population and has a typical onset in adolescence or more rarely in late childhood [1, 2].BD also appears to be associated with cognitive impairment and low psychosocial

https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-023-00322-7
The evidence base for the maintenance effect of lithium in bipolar disorder is far larger than for any other drug (Yatham et al. 2018; Miura et al. 2014; Nestsiarovich et al. 2022) comprising 21 randomised controlled trials comparing lithium with other drugs or placebo (Miura et al. 2014).Data on maintenance treatment comprise 4 trials on valproate, 3 on lamotrigine, 3 on olanzapine and

https://www.abc.net.au/news/health/2021-04-25/lithium-psychiatry-mood-disorders-bipolar-suicide-treatment/100071034
Today, it's considered the gold-standard treatment for bipolar disorder. Walter Brown, a clinical psychiatrist and professor at Brown University in the US, says when lithium-based medication works

https://www.msn.com/en-us/health/other/lithium-treatment-for-bipolar-disorder/ar-BB1kaEaW
In medicine, particularly for the treatment of bipolar disorder, lithium ions (Li+) are used for their mood-stabilizing properties.When lithium is ingested as a medication (in the form of lithium

https://www.youtube.com/watch?v=id987QbZmug
There's no doubt that lithium has a diverse list of uses. But the way that it interacts with our bodies to help treat bipolar disorder is aiding us in better

https://www.nature.com/articles/mp20154
After decades of research, the mechanism of action of lithium in preventing recurrences of bipolar disorder remains only partially understood. Lithium research is complicated by the absence of

https://www.medicalnewstoday.com/articles/bipolar-disorder-treatment-new-evidence-may-explain-limits-of-lithium
In a new study, scientists have discovered a possible explanation of why some people with bipolar disorder respond to lithium — the cornerstone of treatment options — while others do not. The

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221175/
Lithium has been the treatment of choice for patients with bipolar disorder (BD) for nearly 70 years. It is recommended by all relevant guidelines as a first-line treatment for maintenance therapy. In this review, we outline the current state of evidence for lithium in the treatment of BD over the lifespan. First, we summarize the evidence on

https://www.reddit.com/r/bipolar2/comments/1dml5wk/lithium_is_good_for_even_children_with_bipolar/
This is a community for people living with bipolar disorder type 2 (the whole bipolar spectrum is also welcome), their loved ones, and anyone wanting to understand the bipolar spectrum. Members Online

https://theconversation.com/bipolar-disorder-weve-pinpointed-the-brain-areas-which-drive-mood-bias-232854
Bipolar disorder has been described by those who experience it as a double-edged sword. Alongside periods of fluctuating (hypo)manic or depressive moods, many people with bipolar disorder

https://www.northjersey.com/story/news/columnists/mike-kelly/2024/06/21/kyle-matthews-us-military-response-trauma/74139213007/
The doctors who treated him in private psychiatric hospitals say Matthews suffers from post-traumatic stress disorder, bipolar disorder, depression and several other serious mental health problems.

https://www.medicalnewstoday.com/articles/ketamine-bipolar
psychotherapy to help an individual with bipolar disorder navigate daily life and challenge disruptive thoughts, feelings, and behaviors; electroconvulsive therapy (ECT), which stimulates parts of