https://www.mayoclinic.org/diseases-conditions/peripheral-artery-disease/symptoms-causes/syc-20350557
Peripheral artery disease (also called peripheral arterial disease) is a common condition in which narrowed arteries reduce blood flow to the arms or legs. In peripheral artery disease (PAD), the legs or arms — usually the legs — don't receive enough blood flow to keep up with demand. This may cause leg pain when walking (claudication) and

https://my.clevelandclinic.org/health/diseases/14737-peripheral-neuropathy
Peripheral neuropathy is an umbrella term for nerve diseases that affect a specific subdivision of your nervous system. Many different conditions can cause peripheral neuropathy, which means a wide range of symptoms is also possible. Peripheral neuropathy can also affect different body parts, depending on how and why it happens. What this name

https://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/symptoms-causes/syc-20352061
Peripheral neuropathy happens when the nerves that are located outside of the brain and spinal cord (peripheral nerves) are damaged. This condition often causes weakness, numbness and pain, usually in the hands and feet. It also can affect other areas and body functions including digestion and urination. The peripheral nervous system sends

https://www.merckmanuals.com/professional/neurologic-disorders/peripheral-nervous-system-and-motor-unit-disorders/overview-of-peripheral-nervous-system-disorders
Clues that the cause may not be a peripheral nervous system disorder include. Hyperreflexia. Hypertonia. Clonus. Extensor plantar response (eg, Babinski sign) These deficits suggest an upper motor neuron disorder as the cause of weakness. Hyporeflexia is consistent with peripheral nervous system deficits but is nonspecific.

https://www.ninds.nih.gov/health-information/disorders/peripheral-neuropathy
The peripheral nervous system is a large communications network that sends signals between the central nervous system (the brain and spinal cord) and all other parts of the body. Peripheral neuropathy affects millions of people in the U.S. Peripheral nerves send many types of sensory information to the brain, such as the message that your feet

https://medlineplus.gov/peripheralnervedisorders.html
Physical injury ( trauma) that stretches, crushes, squeezes, cuts, or puts pressure on one or more nerves. Some examples of peripheral nerve disorders from physical injury include complex regional pain syndrome and brachial plexus injuries. Health conditions, including: Certain cancers and their treatment ( chemotherapy and radiation therapy ).

https://www.mayoclinicproceedings.org/article/S0025-6196(15)00378-X/fulltext
Peripheral neuropathy is one of the most prevalent neurologic conditions encountered by physicians of all specialties. Physicians are faced with 3 distinct challenges in caring for patients with peripheral neuropathy: (1) how to efficiently and effectively screen (in less than 2 minutes) an asymptomatic patient for peripheral neuropathy when they have a disorder in which peripheral neuropathy

https://www.msdmanuals.com/professional/neurologic-disorders/peripheral-nervous-system-and-motor-unit-disorders/peripheral-neuropathy
Peripheral neuropathy is dysfunction of one or more peripheral nerves (the part of a nerve distal to the root and plexus). It includes numerous syndromes characterized by varying degrees of sensory disturbances, pain, muscle weakness and atrophy, diminished deep tendon reflexes, and vasomotor symptoms, alone or in any combination.

https://www.hopkinsmedicine.org/health/conditions-and-diseases/peripheral-vascular-disease
Peripheral vascular disease (PVD) is a slow and progressive disorder of the blood vessels. Narrowing, blockage, or spasms in a blood vessel can cause PVD. PVD may affect any blood vessel outside of the heart. This includes the arteries, veins, or lymphatic vessels. Organs supplied by these vessels, such as the brain or legs, may not get enough

https://www.msdmanuals.com/en-gb/professional/neurologic-disorders/peripheral-nervous-system-and-motor-unit-disorders/overview-of-peripheral-nervous-system-disorders
Hyporeflexia is consistent with peripheral nervous system deficits but is nonspecific. For example, acute cervical transverse myelitis can mimic Guillain-Barré syndrome Guillain-Barré Syndrome (GBS) Guillain-Barré syndrome is an acute, usually rapidly progressive but self-limited inflammatory polyneuropathy characterized by muscular weakness

https://www.uptodate.com/contents/approach-to-the-patient-with-sensory-loss
Sensory loss may be due to disorders of the central or peripheral nervous system. As in most of neurology, the initial goal when confronted with a patient with sensory loss is localization of the lesion using information from the history and physical examination. This narrows the differential diagnosis and directs further investigations.

https://www.merckmanuals.com/professional/neurologic-disorders/peripheral-nervous-system-and-motor-unit-disorders/nerve-root-disorders
Reviewed/Revised Mar 2024. Nerve root disorders result in segmental radicular deficits (eg, pain or paresthesias in a dermatomal distribution, weakness of muscles innervated by the root). Diagnosis may require neuroimaging, electrodiagnostic testing, and systemic testing for underlying disorders. Treatment depends on the cause but may include

https://en.wikipedia.org/wiki/Peripheral_neuropathy
Peripheral neuropathy, often shortened to neuropathy, ... However, as the disease progresses, deficit(s) becomes more confluent and symmetrical, making it difficult to differentiate from polyneuropathy. Therefore, attention to the pattern of early symptoms is important.

https://www.ncbi.nlm.nih.gov/books/NBK430745/
Patients with peripheral arterial disease (PAD) have decreased lower extremity arterial perfusion which is commonly referred to as "poor circulation." In most cases of PAD, atherosclerotic plaques narrow the arterial flow lumen which restricts blood flow to the distal extremity. Reduced blood flow can cause thigh or calf pain with walking due to temporary ischemia of the leg muscles during

https://www.nysora.com/topics/complications/complications-prevention-neurologic-injury-peripheral-nerve-blocks/
Inadvertent injections of antibiotics, steroids, bovine collagen, botulinum toxin, and local anesthetics into peripheral nerves have all been associated with deleterious neurologic deficits. In a cadaveric model of deliberate intraneural injection of the sciatic nerve, the needle tip disrupted 3% of axons.

https://www.medicalnewstoday.com/articles/peripheral-vision-loss
Peripheral vision loss is also known as tunnel vision or peripheral visual field loss. Peripheral vision loss affects approximately 13% of people over 65 years old. It can affect one or both eyes.

https://journals.lww.com/co-neurology/Fulltext/2013/02000/Peripheral_vestibular_disorders.13.aspx
Description of a frequent and clinically important entity characterized by the combination of central cerebellar and peripheral deficits. 11. Kirchner H, Kremmyda O, Hufner K, et al. Clinical, electrophysiological, and MRI findings in patients with cerebellar ataxia and a bilaterally pathological head-impulse test.

https://www.ncbi.nlm.nih.gov/books/NBK558926/
Vestibular dysfunction is a disturbance of the body's balance system. Etiologies of this disorder are broadly categorized into peripheral and central causes based on the anatomy involved. The symptoms of peripheral and central vestibular dysfunction can overlap, and a comprehensive physical examination can often help differentiate the two. Vestibular disorders usually present acutely, and the

https://www.healthline.com/health/eye-health/peripheral-vision-loss
Stroke. A stroke can cause loss of vision on one side of each eye permanently. This is because a stroke damages one side of the brain. This is a neurological type of vision loss, as your eyes are

https://www.jabfm.org/content/17/5/309
Peripheral neurologic deficits are commonly found during physical examination of older patients. In fact, losses of vibratory sensation and ankle reflexes are so common that they are often listed in geriatric textbooks as normal physical findings in very old people.1,2 However, there is very little published information about their actual prevalence, patterns, and predictors.

https://www.webmd.com/brain/vestibular-disorders-facts
When you have a vestibular disorder, something is interfering with your body's balance system. It could be caused by disease or an injury, but the signals between your inner ear and brain are no

https://www.brighamandwomens.org/neurology/neuro-ophthalmology/visual-field-deficits
Importantly, car accidents may occur because of the decreased peripheral vision. There can be trouble reading, especially when the enlarged blind spot reaches the center of the visual field. While a small visual field deficit might not be very noticeable, a large visual field deficit can clearly have a profound effect on a person's life.

https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.12087
12087 Background: Blood cancer survivors (BCS) sustain peripheral neuromotor decline from toxic therapies but also aging, diabetes and cancer. Peripheral neuropathy (PN) threatens balance and quality of life, and pre-existing nerve deficits raise future PN risk. The evaluation for cellular therapies is an opportunity to identify functional deficits and optimize their management before

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532331/
eye movement deficit 41 perceptual impairment 24 ("Note: patients may have had an isolated visual impairment or combined visual deficits") Not stated: Yes: all patients with a "post‐stroke visual impairment were eligible for inclusion". Jobke 2009: Standard automated perimetry High resolution perimetry (HRP)

https://www.science.org/doi/epdf/10.1126/sciadv.adl1123
cells rejuvenated peripheral immune cells in aged APP/PS1 mice. Furthermore, this approach resulted in reduced central and peripheral Aβ levels, alleviated cerebral Aβ plaque burden, neuronal degeneration, neuroinflammation, and improvement in behavioral deficits. These findings suggest that immune rejuvenation through young BMT may