https://www.mayoclinic.org/diseases-conditions/lupus/symptoms-causes/syc-20365789
The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: Fatigue. Fever. Joint pain, stiffness and swelling. Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose or rashes elsewhere on the body.

https://www.youtube.com/watch?v=0junqD4BLH4
What is systemic lupus erythematosus (SLE)? SLE's an autoimmune disease that can affect any tissue or organ in the body, but most often affects the skin, kid

https://my.clevelandclinic.org/health/diseases/4875-lupus
Healthcare providers sometimes call lupus systemic lupus erythematosus (SLE). It's the most common type of lupus, and means you have lupus throughout your body. Other types include: Cutaneous lupus erythematous: Lupus that only affects your skin. Drug-induced lupus: Some medications trigger lupus symptoms as a side effect. It's usually

https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-systemic-lupus-erythematosus-in-adults
DIAGNOSIS — The diagnosis of systemic lupus erythematosus (SLE) is based upon the judgment of an experienced clinician who recognizes characteristic constellations of symptoms and signs in the setting of supportive serologic studies after excluding alternative diagnoses. This is often challenging due to the great variability in the expression

https://www.healthline.com/health/systemic-lupus-erythematosus
Systemic lupus erythematosus (SLE) is the most common type of lupus, a chronic autoimmune disease. Symptoms include fatigue, joint pain, and rashes across your nose and cheeks.

https://www.ncbi.nlm.nih.gov/books/NBK535405/
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystemic involvement. The condition has several phenotypes, with varying clinical presentations from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement. Several immunopathogenic pathways play a role in the development of SLE. Hargraves described the lupus erythematosus (LE

https://www.niams.nih.gov/health-topics/lupus/basics/symptoms-causes
Change over time. Some symptoms happen when the disease causes inflammation in organs. Symptoms of lupus can include: Arthritis, causing painful and swollen joints and morning stiffness. Fevers. Feeling tired often (fatigue). Rashes. Hair loss. Sores, which are usually painless, in the nose and mouth.

https://www.niams.nih.gov/health-topics/lupus/diagnosis-treatment-and-steps-to-take
Overview, Symptoms, & Causes Diagnosis, Treatment, & Steps to Take More Info Diagnosis of Systemic Lupus Erythematosus (Lupus) Lupus can be difficult to diagnose because it has many symptoms that come and go and can mimic symptoms of other disorders or diseases. When speaking to your doctor about your symptoms, be sure to include symptoms that

https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/autoimmune-rheumatic-disorders/systemic-lupus-erythematosus-sle
Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and autoimmune cytopenias.

https://www.msdmanuals.com/home/bone,-joint,-and-muscle-disorders/autoimmune-disorders-of-connective-tissue/systemic-lupus-erythematosus-sle
More Information. |. Systemic lupus erythematosus is a chronic autoimmune inflammatory connective tissue disorder that can involve joints, kidneys, skin, mucous membranes, and blood vessel walls. Problems in the joints, nervous system, blood, skin, kidneys, gastrointestinal tract, lungs, and other tissues and organs can develop.

https://www.cdc.gov/lupus/about/index.html
What it is. Systemic lupus erythematosus (SLE), often just called lupus, is: An autoimmune disease. This means the body's immune system mistakenly attacks its own healthy cells and tissues, leading to inflammation and damage in organs or systems. A long-term (chronic) disease that affects many different parts of the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310637/
Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogenous, reflecting the complex

https://www.niams.nih.gov/health-topics/lupus
Systemic lupus erythematosus (lupus) is a chronic (long-lasting) autoimmune disease that can affect many parts of the body. Lupus occurs when the immune system, which normally helps protect the body from infection and disease, attacks its own tissues. This attack causes inflammation, and in some cases permanent tissue damage, which can be

https://www.mayoclinic.org/diseases-conditions/lupus/diagnosis-treatment/drc-20365790
Complete blood count. This test measures the number of red blood cells, white blood cells and platelets as well as the amount of hemoglobin, a protein in red blood cells. Results may indicate you have anemia, which commonly occurs in lupus. A low white blood cell or platelet count may occur in lupus as well. Erythrocyte sedimentation rate.

https://bestpractice.bmj.com/crawler/topics/en-gb/103
Systemic lupus erythematosus (SLE) is a generalised disorder that can affect any system. Symptoms and signs may accumulate over time. The diagnosis is made using 2019 criteria recommended by the American College of Rheumatology and the European League Against Rheumatology. Treatments for mild to moderate serositis or arthritis include

https://www.lupus.org/resources/what-is-systemic-lupus-erythematosus-sle
SLE can cause inflammation of multiple organs or organ systems in the body, either acutely or chronically. In contrast, cutaneous lupus (CLE), is limited to the skin, although in some patients, it may eventually progress to SLE. Drug-induced lupus can be caused by certain prescription medications. It has many of the same symptoms as SLE but

https://emedicine.medscape.com/article/332244-overview
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that has protean manifestations and follows a relapsing and remitting course. ... Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. Signs and symptoms of SLE. ... with peak events occurring in the

https://www.verywellhealth.com/systemic-lupus-erythematosus-4782139
Systemic lupus erythematosus (SLE), also known as lupus, is an autoimmune disease in which the immune system mistakenly attacks healthy tissues throughout the body. With lupus, a person's overactive immune system causes inflammation that damages connective tissues, including cartilage and the lining of blood vessels. SLE is one of several types of lupus and the most common form.

https://www.epocrates.com/online/diseases/103/systemic-lupus-erythematosus
Systemic lupus erythematosus (SLE) is a generalized disorder that can affect any system. Symptoms and signs may accumulate over time. The diagnosis is made using 2019 criteria recommended by the American College of Rheumatology and the European League Against Rheumatology.

https://www.aafp.org/pubs/afp/issues/2023/0400/systemic-lupus-erythematosus.pdf
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects the cardiovascular, gastrointestinal, hematologic, integumentary, musculoskeletal, neuropsychiatric, pulmonary, renal, and

https://patient.info/skin-conditions/lupus-systemic-lupus-erythematosus
Lupus is the short name for the condition called systemic lupus erythematosus (SLE). It can cause various symptoms, the most common being joint pains, skin rashes and tiredness. Problems with kidneys and other organs can occur in severe cases. Lupus is an autoimmune condition. Treatment includes anti-inflammatory painkillers to ease joint pains

https://www.medicalnewstoday.com/articles/325263
Systemic lupus erythematosus (SLE) is the most common form of lupus. It is a chronic condition that can affect multiple tissues and organs. As a result, the symptoms of SLE vary widely. Although

https://www.kidney.org/atoz/content/lupus-nephritis
No one knows what causes the disease. Your family history and things in your environment such as infections, viruses, toxic chemicals or pollutants (car fumes, factory smoke) may play a role in causing the disease. Men and women of all ages and races get lupus. However, about 90 percent of people diagnosed with lupus are women.

https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-024-01941-1
Observational studies have found a link between two autoimmune diseases, namely, primary sclerosing cholangitis (PSC) and systemic lupus erythematosus (SLE). However, the relationship remains unclear. Bidirectional Mendelian randomization (MR) analysis and statistical methods, including inverse variance weighting, weighted median, and MR-Egger tests, were performed using data from genome-wide

https://pubmed.ncbi.nlm.nih.gov/38933624/
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by type II and type III hypersensitivity reactions that affect multiple organs, including the joints, heart, lungs, brain, skin, and kidneys. Patients with SLE can experience a range of symptoms, ranging from fever and joint pain to a distinctive butterfly facial rash.

https://www.niams.nih.gov/health-topics/lupus/basics/diagnosis-treatment-and-steps-to-take
When speaking to your doctor, be sure to include symptoms that you no longer have. Diagnosing lupus can include: Your medical and family history and symptoms. A complete physical exam. Laboratory blood and urine tests. A biopsy of the skin or kidney by taking a small sample of tissue to look at under a microscope.

https://obgyn.onlinelibrary.wiley.com/doi/10.1111/aogs.14880
Introduction. Women with systemic lupus erythematosus (SLE) have a higher risk for fetal and maternal complications. We aimed to investigate maternal and fetal complications in pregnant women with SLE compared to a high-risk pregnancy cohort (HR) from a tertiary university center and a standard-risk general population (SR) from the Austrian Birth Registry.

https://ard.bmj.com/content/early/2024/04/12/ard-2024-225664
Introduction Systemic lupus erythematosus with antiphospholipid syndrome (SLE-APS) represents a challenging SLE endotype whose molecular basis remains unknown. Methods We analysed whole-blood RNA-sequencing data from 299 patients with SLE (108 SLE-antiphospholipid antibodies (aPL)-positive, including 67 SLE-APS; 191 SLE-aPL-negative) and 72 matched healthy controls (HC).

https://link.springer.com/article/10.1007/s12519-024-00811-4
Background The role of type I interferon (IFN-I) signaling in systemic lupus erythematosus (SLE) has been well established. However, unanswered questions remain regarding the applicability of these findings to pediatric-onset SLE. The aim of this review is to provide an overview of the novel discoveries on IFN-I signaling in pediatric-onset SLE. Data sources A literature search was conducted

https://www.msn.com/en-us/health/medical/understanding-the-symptoms-of-lupus-erythematosus/ar-AA1dJh5i
The symptoms of the complicated autoimmune illness Lupus erythematosus are varied. For the problem to be identified and managed early on, it is essential to recognize these signs.