https://medicalxpress.com/news/2024-06-stem-cell-therapy-breakthrough-diabetes.html
An experimental stem cell therapy can essentially cure type 1 diabetes by restoring insulin production in some patients, early clinical trial results show. Seven out of 12 patients no longer

https://www.nature.com/articles/d41586-021-01842-x
How stem cells could fix type 1 diabetes. Trials to replace the pancreatic β cells that are destroyed by this autoimmune disease are raising hopes of a cure. Encapsulated stem cell-derived islets

https://www.verywellhealth.com/how-stem-cells-are-helping-cure-type-1-diabetes-5212812
A man living with severe type 1 diabetes who is part of a clinical trial by Vertex Pharmaceuticals appears to be have been functionally cured of the disease thanks to a new treatment involving stem cells. Brian Shelton, aged 64, received an infusion of cells in June that "taught" the pancreas to produce insulin —something that the bodies

https://hsci.harvard.edu/news/new-therapy-treating-type-1-diabetes
Promising early results show that longstanding Harvard Stem Cell Institute (HSCI) research may have paved the way for a breakthrough treatment of Type 1 diabetes. Utilizing research from the Melton Lab, Vertex Pharmaceuticals has developed VX-880, an investigational stem cell-derived, fully differentiated pancreatic islet cell replacement therapy for people with type 1 diabetes (T1D). In

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346484/
Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes insulin deficient and hyperglycemic. Administration or injection of exogenous insulin cannot mimic the endogenous insulin secreted by a healthy pancreas.

https://www.healthday.com/health-news/diabetes/stem-cell-therapy-could-be-breakthrough-against-type-1-diabetes
TUESDAY, June 25, 2024 (HealthDay News) -- An experimental stem cell therapy can essentially cure type 1 diabetes by restoring insulin production in some patients, early clinical trial results show.. Seven out of 12 patients no longer needed daily insulin shots after receiving a full dose of the gene therapy, dubbed VX-800, researchers reported Friday at the American Diabetes Association's

https://www.nytimes.com/2021/11/27/health/diabetes-cure-stem-cells.html
Brian Shelton may be the first person cured of Type 1 diabetes. "It's a whole new life," Mr. Shelton said. "It's like a miracle.". Amber Ford for The New York Times. Brian Shelton's

https://www.endocrine.org/news-and-advocacy/news-room/2022/stem-cell-based-therapy-shows-promise-in-treating-high-risk-type-1-diabetes
An investigative stem cell-based therapy called PEC-Direct, designed to act as a replacement pancreas, has the potential to provide blood sugar control in patients with high-risk type 1 diabetes, suggests a clinical study presented Saturday, June 11 at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga. The study found multiple patients using the new treatment had clinically

https://www.nature.com/articles/d42859-021-00021-2
Type 1 diabetes (T1D) is particularly suited to this approach, as transplantation of the insulin-producing pancreatic β-cells could provide long-lasting therapy or even a cure. By the early 2000s

https://news.med.miami.edu/diabetes-research-institute-announces-transplantation-for-type-1-diabetes/
The Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine unveiled an innovative approach at the American Diabetes Association's (ADA) 84th Scientific Sessions that highlights the potential of human, stem cell-derived islets combined with an immunomodulatory microgel to reverse Type 1 diabetes (T1D).

https://www.webmd.com/diabetes/news/20231211/stem-cell-therapy-implant-shows-promise-for-type-1-diabetes
Dec. 11, 2023 - An experimental device containing millions of stem cells significantly reduced the need for insulin shots among people with type 1 diabetes, according to a new study - a

https://www.statnews.com/2024/06/21/vertex-stem-cell-therapy-trial-type-1-diabetes/
O RLANDO — Twelve people with type 1 diabetes who received a therapy derived from stem cells were able to produce enough of their own insulin to maintain healthy blood glucose levels 90 days

https://diabetes.org/newsroom/novel-stem-cell-derived-islet-cell-therapy-continues-show-promise-achieving-insulin-independence-individuals-type-1-diabetes
"These new findings demonstrate the potential of stem cell-derived islets as a future treatment for patients with type 1 diabetes, signaling a new era that could potentially remove the need for exogenously administered insulin to achieve glycemic control," said Trevor W. Reichman, MD, PhD, Surgical Director of Pancreas and Islet Cell

https://diatribe.org/diabetes-research/viacyte-and-crispr-introduce-new-stem-cell-therapy-type-1-diabetes
In a collaboration between ViaCyte and CRISPR Therapeutics, a new clinical trial is investigating a stem cell therapy that may eventually help millions with type 1 diabetes. Researchers have long sought a cell-based "cure" for type 1 diabetes, and in recent years, this goal has seemed more attainable. Since the condition results from the

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-024-03636-0
Over the past decade, there had been progress in the development of cell therapy for insulin-dependent diabetes. Nevertheless, important hurdles that need to be overcome still remain. Protocols for the differentiation of pluripotent stem cells into pancreatic progenitors or fully differentiated β-cells have been developed. The resulting insulin-producing cells can control chemically induced

https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300238
We conducted a phase 1/2, randomized, double-blind, placebo-controlled trial of the autologous dendritic cell therapy AVT001 that included participants at least 16 years of age, within 1 year of T1D diagnosis, and with ex vivo evidence of a defect in Q/E CD8+ Treg function.

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01793-6
Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes insulin deficient and hyperglycemic. Administration or injection of exogenous insulin cannot mimic the endogenous insulin secreted by a healthy pancreas. Pancreas and islet transplantation have emerged as

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972968/
There are many advantages of stem cells in the treatment of T1DM: first of all, stem cells such as bone marrow-derived stem cells (MSCs) can easily be obtained from bone marrow, umbilical cord blood, adipose tissue, etc. compared with islet and pancreas; secondly, the pluripotent stem cells could differentiate into β-cells and increase the

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007200/
To accurately identify clinical trials of stem cell transplantation in DM patients, a search was performed using a combination of medical subject heading (MeSH) terms and text words: "diabetes mellitus, type 1" or "diabetes mellitus, type 2" and "stem cell transplantation" and "therapy" or "therapeutic use." Inclusion and Exclusion Criteria

https://www.sacbee.com/press-releases/article289491268.html
About the Diabetes Research ... as a potential cure for Type 1 Diabetes without the need for life-long immunosuppression. ... C, Lanzoni G. Reversal of diabetes by human stem cell-derived islets

https://www.news-medical.net/news/20231127/New-stem-cell-based-treatment-for-Type-1-diabetes-can-reduce-dependence-on-daily-insulin-injections.aspx
University of British Columbia Nov 27 2023. An innovative stem cell-based treatment for Type 1 diabetes can meaningfully regulate blood glucose levels and reduce dependence on daily insulin

https://www.usnews.com/news/health-news/articles/2023-10-04/stem-cell-therapy-could-be-breakthrough-against-type-1-diabetes
Given via an infusion, VX-880 are stem cell-derived, insulin-producing islet cells that essentially replace the dysfunctional islet cells in people with type 1 diabetes. The study was funded by VX

https://www.cnbc.com/2022/03/26/stem-cells-may-finally-offer-a-cure-for-type-1-diabetes.html
Diabetes effects 537 million people globally, but there's been no promising cure. Now, stem cells may finally offer a way to create new insulin-making cells.

https://www.diabetes.org.uk/about-us/news-and-views/stem-cell-therapy
Stem cell therapies at the moment are being tested in people with type 1 diabetes and frequent hypos and hypo unawareness, for whom this pioneering treatment could be life-saving. But as research advances, we hope stem cells-turned-beta cells could also be used to boost beta cell supply in people with type 2 diabetes and help them to make

https://pubmed.ncbi.nlm.nih.gov/32641151/
Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes insulin deficient and hyperglycemic. Administration or injection of exogenous insulin cannot mimic the endogenous insulin secreted by a healthy pancreas.

https://www.thenationalnews.com/health/2024/06/28/how-medical-advances-can-help-half-a-billion-people-living-with-diabetes/
Such patients could, like those with Type 1 diabetes, profit from receiving beta cells that have been derived from stem cells, Dr Salem said. Indeed recent reports claim that a man in China was "cured of Type 2 diabetes" after receiving laboratory-grown insulin-producing cells derived from stem cells.

https://www.medicinenet.com/stem_cell_therapy_for_type_1_diabetes/news.htm
An experimental stem cell therapy can essentially cure type 1 diabetes by restoring insulin production in some patients, early clinical trial results show.. Seven out of 12 patients no longer needed daily insulin shots after receiving a full dose of the gene therapy, dubbed VX-800, researchers reported Friday at the American Diabetes Association's annual meeting in Orlando, Fla.

https://www.mskcc.org/news/discovery-stem-cell-type-1-diabetes-holds-potential-improving-cancer-immunotherapy-sloan-kettering-institute-scientists-say
Modeling Diabetes in Mice. Type 1 diabetes is caused when the body starts making T cells that specifically recognize and kill the insulin-producing cells of the pancreas. These are called beta cells. When 80% or more of the beta cells are killed, the body can no longer regulate the level of glucose in the blood and diabetes results.

https://www.diabetes.org.uk/about-us/news-and-views/breaking-research-news-american-diabetes-association
Vertex's venture into man-made beta cells Stem cells can be coaxed to shape-shift into other types of cells in the body, including insulin-making beta cells. Scientists are using them to produce a man-made supply of beta cells that could be transplanted into people with type 1 diabetes, replacing those that the immune system has destroyed.

https://www.msn.com/en-us/health/other/diabetes-cured-for-first-time-in-stem-cell-study-but-theres-a-less-expensive-alternative/ar-BB1oF1cG
59-year-old type 2 diabetes patient is 'cured' after stem cell therapy. In July 2021, a man who had been living with type 2 diabetes for 25 years underwent a stem cell transplant. He was