https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133947/
d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. ... the LSD-induced psychosis is a useful model to test the therapeutic efficacy of potential novel antipsychotic drugs

https://pubmed.ncbi.nlm.nih.gov/27886063/
Abstract. d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. The goal of this review was to understand the mechanism of action of psychotic-like effects of LSD.

https://www.mdpi.com/1422-0067/17/11/1953
d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. The goal of this review was to understand the mechanism of action of psychotic-like effects of LSD. We searched Pubmed, Web of Science, Scopus, Google Scholar and articles

https://pubmed.ncbi.nlm.nih.gov/6870484/
Abstract. We studied whether patients hospitalized for LSD psychosis are clinically separable from acute schizophrenics. The family histories, manifest symptoms, premorbid adjustment, and profiles on an extensive test battery were analyzed for 52 LSD psychotics and 29 matched first-break schizophrenics. The LSD patients did not differ from

https://www.researchgate.net/publication/310785771_d-Lysergic_Acid_Diethylamide_LSD_as_a_Model_of_Psychosis_Mechanism_of_Action_and_Pharmacology
D-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in

https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/abs/phenomenological-comparison-of-lsd-and-schizophrenic-states/BDCA49207B7E85C3A730F065162F958F
The accidental discovery of d-lysergic acid diethylamide-25 (LSD) by Hofman in 1943 brought this possibility closer to realization than ever before. ... 'A comparison of the visual hallucinations in schizophrenia with those induced by mescaline and LSD-25', in ... madness and healing: Mystical experiences as possible link between psychosis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910402/
Bercel N., Travis L., Olinger L., Dreikurs E. (1956) Model psychoses induced by LSD-25 in normals. I. Psychophysiological ... Liester M. (2014) A review of lysergic acid diethylamide (LSD) in the treatment of ... Babler A., Vogel H., Hell D. (1998) Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2

https://www.nature.com/articles/npp201786
The present article reviews studies on the clinical pharmacology and use of lysergic acid diethylamide (LSD) in psychiatry research, with a focus on recent clinical studies. Older studies that

https://www.sciencedirect.com/science/article/pii/B9780128002124000807
Abstract. The potent classic hallucinogen, lysergic acid diethylamide (LSD), has a rich history that intertwines with our current understanding of schizophrenia and psychosis. This chapter explores that history and reviews the discovery of serotonin, LSD, and the early use of LSD to model psychosis in both animals and humans.

https://mdpi-res.com/d_attachment/ijms/ijms-17-01953/article_deploy/ijms-17-01953.pdf?version=1479887843
5-HT1A as an agonist. LSD also modulates the Ventral Tegmental Area, at higher doses, by stimulating dopamine D2, Trace Amine Associate receptor 1 (TAAR1) and 5-HT2A. More studies clarifying the mechanism of action of the psychotic-like symptoms or psychosis induced by LSD in humans are needed.

https://www.nature.com/articles/s41386-022-01297-2
The 100 and 200 µg doses of lysergic acid diethylamide (LSD) only moderately increased blood pressure compared with placebo, whereas 15 and 30 mg psilocybin induced more pronounced increases in

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326711/
The representative drugs that can cause psychosis are amphetamine, scopolamine, ketamine, phencyclidine (PCP), and lysergic acid diethylamide (LSD) . Specifically, psychosis induced by amphetamine had shed light on schizophrenia studies by transitioning the focus on psychoanalytic perspectives to the neurotransmitter perspective [ 8 ].

https://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2008.00059.x
Lysergic acid diethylamide (LSD) was synthesized in 1938 and its psychoactive effects discovered in 1943. It was used during the 1950s and 1960s as an experimental drug in psychiatric research for producing so-called "experimental psychosis" by altering neurotransmitter system and in psychotherapeutic procedures ("psycholytic" and "psychedelic" therapy).

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/493118
Thus, in most respects the LSD psychotics were fundamentally similar to schizophrenics in genealogy, phenomenology, and course of illness. The findings supported a model of LSD psychosis as a drug-induced schizophreniform reaction in persons vulnerable to both substance abuse and psychosis. • We studied whether patients hospitalized for LSD

https://www.pnas.org/doi/full/10.1073/pnas.1815129116
Lysergic acid diethylamide (LSD) is a psychedelic drug that reliably induces an altered state of consciousness. Interest in psychedelic compounds is growing due to their remarkable potential for understanding altered neural states and potential clinical applications. However, there are major knowledge gaps regarding LSD's neuropharmacology.

https://www.nature.com/articles/s41386-022-01301-9
De Gregorio D, Comai S, Posa L, Gobbi G. d-Lysergic acid diethylamide (LSD) as a model of psychosis: mechanism of action and pharmacology. Int J Mol Sci. 2016;17:1953.

https://www.therecoveryvillage.com/lsd-addiction/psychosis-and-lsd/
Psychosis and lysergic acid diethylamide, more commonly known as LSD, are popular topics for urban legends.When people started using LSD as a recreational drug in the 1960s, some spoke of it in whispers as a gateway to spiritual enlightenment, while others warned of bad trips and permanent highs that fried people's brains and turned them into "acid casualties."

https://pubmed.ncbi.nlm.nih.gov/13545992/
[Model psychosis induced by lysergic acid diethylamide; various psychopathological aspects of experimental LSD poisoning in normal subjects]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661800/
Psychedelics activate some neurotransmitters, i.e., serotonergic, and glutamatergic, that are also impaired in schizophrenia. Therefore, the neurobiological background of psychedelics and schizophrenia is partially similar. Another important aspect to discuss is the perspective of using psychedelics in schizophrenia therapy.

https://archive.org/details/gov.archives.arc.1662201
National Archives - Schizophrenic Model Psychosis Induced by Lysergic Acid Diethylamide (LSD) - National Security Council. Central Intelligence Agency. (09/18/1947 - 12/04/1981). - This film provides footage of University of California medical tests with LSD. - DVD Copied by IASL Scanner John Williams. - ARC 1662201 / LI 263.1153

https://www.mdpi.com/2227-9032/12/12/1172/xml
Current major neurobiological theories of schizophrenia trace their roots back to the effects of various substances: the serotonergic model stemmed from observations of lysergic acid diethylamide (LSD) , the dopamine hypothesis emerged from studies on amphetamines, and the glutamatergic model was influenced by research on phencyclidine (PCP

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603820/
Abstract. All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD) in healthy subjects or patients in the last 25 years are reviewed herein. There were five recent studies in healthy participants and one in patients. In a controlled setting, LSD acutely induced bliss, audiovisual synesthesia, altered meaning

https://www.nature.com/articles/1395848
Hallucinogenic drugs such as lysergic acid diethylamide (LSD) have profound effects on humans including hallucinations and detachment from reality. ... LSD- induced signaling events within cells

https://www.cambridge.org/core/journals/psychological-medicine/article/abs/lsd-madness-and-healing-mystical-experiences-as-possible-link-between-psychosis-model-and-therapy-model/0D306E3797D2BA828247A781E31D3022
Methods. In a randomized, double-blind, placebo-controlled, crossover design, 24 healthy volunteers received 50 μg d-lysergic acid diethylamide (LSD) or inactive placebo.Psychotic experience was assessed by aberrant salience (Aberrant Salience Inventory, ASI), therapeutic potential by suggestibility (Creative Imagination Scale, CIS) and mindfulness (Five Facet Mindfulness Questionnaire, FFMQ

https://link.springer.com/article/10.1007/s40429-024-00581-z
The term "classic psychedelics" refers to the serotonin-2A receptor (5-HT 2A R) agonists or partial agonists psilocybin/psilocin (magic mushrooms), dimethyltryptamine (DMT; ayahuasca), lysergic acid diethylamide (LSD), and mescaline (peyote/San Pedro), which profoundly alter interceptive, somatic, emotional, and cognitive perception, and can initiate revelatory and mystical-type experiences.