https://www.mayoclinic.org/diseases-conditions/polycystic-kidney-disease/symptoms-causes/syc-20352820
Polycystic kidney disease (PKD) is an inherited disorder in which clusters of cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. Cysts are noncancerous round sacs containing fluid. The cysts vary in size, and they can grow very large.

https://www.kidney.org/atoz/content/polycystic
Polycystic kidney disease (also called PKD) causes numerous cysts to grow in the kidneys. These cysts are filled with fluid. If too many cysts grow or if they get too big, the kidneys can become damaged. PKD cysts can slowly replace much of the kidneys, reducing kidney function and leading to kidney failure. In the United States about 600,000

https://www.niddk.nih.gov/health-information/kidney-disease/polycystic-kidney-disease/what-is-pkd
PKD is a form of chronic kidney disease (CKD) that reduces kidney function and may lead to kidney failure. PKD also can cause other complications, or problems, such as high blood pressure, cysts in the liver, and problems with blood vessels in your brain and heart. Polycystic kidney disease is a genetic disorder that causes many fluid-filled

https://www.mayoclinic.org/diseases-conditions/polycystic-kidney-disease/diagnosis-treatment/drc-20352825
Diagnosis. For polycystic kidney disease, certain tests can detect the size and number of kidney cysts you have and evaluate the amount of healthy kidney tissue, including: Ultrasound. During an ultrasound, a wandlike device called a transducer is placed on your body. It emits sound waves that are reflected back to the transducer — like sonar.

https://my.clevelandclinic.org/health/diseases/5791-polycystic-kidney-disease
What is polycystic kidney disease? Polycystic kidney disease (PKD) causes cysts (fluid-filled growths) to develop in the kidneys. PKD is a genetic disorder, meaning you have to have a mutated (changed) gene to get the disorder. PKD isn't the same as simple kidney cysts, which are usually harmless. PKD is a serious type of chronic kidney

https://www.hopkinsmedicine.org/health/conditions-and-diseases/polycystic-kidney-disease
Polycystic kidney disease (PKD) is a genetic condition marked by the growth of numerous cysts (fluid-filled sacs) in the kidneys. The cysts become larger and the kidneys enlarge along with them. Slowly, the kidneys lose their ability to filter waste from the blood, which leads to progressive loss of kidney function and eventually to kidney

https://www.niddk.nih.gov/health-information/kidney-disease/polycystic-kidney-disease
What is PKD? Polycystic kidney disease is a genetic disorder that causes many cysts to grow in the kidneys. PKD cysts cause high blood pressure and problems with blood vessels in the brain and heart. Cysts in the liver can also occur with PKD.

https://en.wikipedia.org/wiki/Polycystic_kidney_disease
Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidney. These cysts may begin to develop in utero, in infancy, in childhood, or in adulthood. Cysts are non-functioning tubules filled with fluid pumped into them

https://bestpractice.bmj.com/crawler/topics/en-gb/481
Polycystic kidney disease (PKD) is an inherited renal cystic disease, of which autosomal-dominant polycystic kidney disease is the more common form. ... and abdominal wall hernias. Interfamilial and intrafamilial variability is explained to a large extent by its genetic heterogeneity and modifier genes. Long-term complications include

https://www.msdmanuals.com/en-gb/home/kidney-and-urinary-tract-disorders/cystic-kidney-disorders/polycystic-kidney-diseasepkd
Polycystic kidney disease is caused by an inherited gene defect. Some people have such mild symptoms that they do not realize they have a disorder, but others have pain in the side, blood in the urine, high blood pressure, and crampy pain caused by kidney stones. Diagnosis is based on ultrasonography, computed tomography, or magnetic resonance

https://www.healthline.com/health/polycystic-kidney-disease
Polycystic kidney disease is an inherited kidney disorder that causes fluid-filled cysts to form in the kidneys. Learn more about the condition and treatment options.

https://www.yalemedicine.org/conditions/polycystic-kidney-disease
Polycystic kidney disease causes fluid-filled sacs called cysts to grow in the kidneys. The cysts can become large and cause scarring, which eventually harms the organs' function. This disease is caused by a gene mutation, usually passed down by a parent. While symptoms often first appear in young adulthood, polycystic kidney disease, or PKD

https://www.ncbi.nlm.nih.gov/books/NBK373386/
Polycystic kidney disease (PKD) is characterized by the presence of fluid-filled cysts in the kidneys. It is the fourth most common cause of chronic renal insufficiency or end-stage kidney disease. This book focuses on the basic and clinical aspects of the burgeoning PKD research under three sections. Section 1 provides a comprehensive guide to the diagnosis, management and treatment of PKD.

https://patient.info/kidney-urinary-tract/chronic-kidney-disease-leaflet/polycystic-kidney-disease
What is polycystic kidney disease? A cyst is a fluid-filled sac. Cysts occur in various sizes, in various conditions and in various parts of the body. Polycystic means many cysts.. Polycystic kidney disease is a condition where many cysts develop in the kidneys. The cysts are non-cancerous (benign) and develop from some of the kidney tubules.

https://www.verywellhealth.com/how-polycystic-kidney-disease-is-diagnosed-5207185
Differential Diagnosis. If your healthcare provider suspects you have polycystic kidney disease (PKD), they will likely use imaging tests to diagnose the condition. Imaging tests such as ultrasounds, CT scans, and MRI tests can detect how many cysts you have on your kidneys and what size they are. This article will explain how a person can be

https://newsnetwork.mayoclinic.org/discussion/consumer-health-whats-the-difference-between-kidney-cysts-and-polycystic-kidney-disease/
Polycystic kidney disease is an inherited disorder in which clusters of noncancerous cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. The cysts vary in size and can grow very large. Having many cysts or large cysts can damage your kidneys. Polycystic kidney disease is one of the most

https://www.epocrates.com/online/diseases/481/polycystic-kidney-disease
Polycystic kidney disease (PKD) is an inherited renal cystic disease, of which autosomal-dominant polycystic kidney disease is the more common form. Characterized by renal cysts, extrarenal cysts, intracranial aneurysms, aortic root dilation and aneurysms, mitral valve prolapse, and abdominal wall hernias.

https://www.youtube.com/watch?v=M4jf9iKPkgg
A look Polycystic Kidney Disease, including its pathophysiology, causes (including Autosomal Dominant vs Autosomal Recessive), as well as its signs and sympt

https://texaskidneyinstitute.com/polycystic-kidney-disease-explained/
Polycystic kidney disease (PKD) is a kidney condition that causes cysts to develop in the kidneys. According to the National Kidney Foundation, PKD is a genetic disorder that affects around 600,000 people in the United States and occurs equally in men and women of all races. PKD causes about 5% of all kidney failure and is the fourth leading cause of kidney failure in the U.S.

https://www.kidney.org.uk/adult-polycystic-kidney-disease
Adult polycystic kidney disease. If you would like to discuss your kidney diagnosis with our trained members of staff ring the free to call number 0800 169 0936. The NKF Helpline is available Monday to Thursday 08:30 am - 5:00 pm Friday 8.30 am - 12.30 pm on 0800 169 09 36 or email helpline@kidney.org.uk.

https://www.health.harvard.edu/a_to_z/polycystic-kidney-disease-a-to-z
Polycystic kidney disease causes numerous cysts (non-cancerous growths) to form in both kidneys. It is a genetic disease, meaning you inherit it from your parents. About 600,000 Americans have polycystic kidney disease. The kidneys are a pair of bean-shaped organs that sit in the upper part of the abdomen. They filter wastes and extra fluid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108786/
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by slow but progressive enlargement of the kidneys with renal failure occurring by the fifth to sixth decade of life. 1 The disease occurs in approximately 1:800 to 1:1,000 people and accounts for 2.5% of all cases of end-stage renal disease. 1, 2 Clinically, ADPKD presents

https://www.nature.com/articles/s42255-020-0232-7
Cassina, L., Boletta, A. Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?. Nat Metab 2, 659-660 (2020

https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-024-03643-6
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by continuous enlargement of cysts and loss of kidney function, leading to end stage kidney diseases requiring dialysis or transplant in the majority of patients [].Disease severity is variable in affected individuals even within members of the same family [].Prognostic markers are important for monitoring disease

https://myrgv.com/local-news/2024/06/21/mcallen-kidney-doctor-credits-serendipity-for-major-medical-discovery/
Throughout graduate school he focused his efforts on understanding polycystic kidney disease, a disease that affects half a million people in the county and fourth leading cause of kidney failure and needing dialysis. ... He explained that he is grateful to have been faced with those challenges and the impact it made in his life.

https://www.semanticscholar.org/paper/Cilia-to-basement-membrane-signalling-is-a-driver-Mazloum-Lapin/49a3c0d50ee335d81768c3eb1fab1b66456c79b7
It is found that cilia and polycystin-1 shape the tubular basement membrane (TBM) and it is unveiled that cilia to TBM signalling controls kidney shape. Autosomal dominant polycystic kidney disease (ADPKD), which affects around 4 million patients worldwide, is characterized by the formation of multiple tubule derived cysts, which grossly enlarge both kidneys and progressively compromise renal

https://pubmed.ncbi.nlm.nih.gov/8144700/
Studies in a murine model of human autosomal recessive polycystic kidney disease, the C57BL/6J cpk/cpk (CPK) mouse have demonstrated quantitative (increased activity) and qualitative (apical membrane distribution) alterations in Na+,K(+)-adenosine triphosphatase activity that mediate tubular cyst formation. Proximal tubular cyst formation in