https://www.webmd.com/brain/what-are-motor-neuron-diseases
PLS is similar to ALS, but it affects only upper motor neurons. It causes weakness and stiffness in the arms and legs, a slowed walk, and poor coordination and balance. Speech also becomes slow

https://www.ninds.nih.gov/health-information/disorders/motor-neuron-diseases
Kennedy's disease is an inherited lower motor neuron disorder that affects men. The onset of symptoms varies, but usually begins between the ages of 20 and 40. Kennedy's disease is also known as spinal and bulbar muscular atrophy (SBMA), bulbo-spinal muscular atrophy, or X-linked spinal and bulbar muscular atrophy.

https://www.ncbi.nlm.nih.gov/books/NBK560774/
Introduction. Motor neuron disease (MND) is said to be a progressive neurological disorder that presents with both lower motor neurons (anterior horn cells that project from the brainstem and the spinal cord to the muscle) and upper motor neuron signs (neurons that project to the brainstem and spinal cord from higher cortical centers).

https://www.mndassociation.org/about-mnd/mnd-explained/what-is-mnd
MND is the short term for motor neurone disease, which affects the nerves known as motor neurones. These nerves are found in the brain and spinal cord and they help tell your muscles what to do. If you have MND, this means your movement will be affected and you are likely to get a wide range of symptoms. Select from the following for basic

https://www.mndassociation.org/sites/default/files/2022-11/Introduction%20to%20MND.pdf
With MND, motor neurones gradually stop telling your muscles how to move. When muscles no longer move, they become weak, which can also lead to stifness and loss of muscle mass (wasting). MND is a life-shortening illness that can afect how you walk, talk, eat, drink, breathe, think and behave.

https://en.wikipedia.org/wiki/Motor_neuron_diseases
Signs and symptoms A man with amyotrophic lateral sclerosis (ALS). (A) He needs assistance to stand. (B) Advanced atrophy of the tongue. (C) There is upper limb and truncal muscle atrophy with a positive Babinski sign. (D) Advanced thenar muscle atrophy.. Signs and symptoms depend on the specific disease, but motor neuron diseases typically manifest as a group of movement-related symptoms.

https://www.mndassociation.org/sites/default/files/2023-02/LW01%20Motor%20neurone%20disease%20%28MND%29_0.pdf
metimes called motor neurons). These are the nerves in the brain and spinal cord that. control how your muscles work. This means that messages gradually stop reaching muscles, leading to weakness, stifness and. loss of muscle mass (wasting).MND is progressive, which mean.

https://www.ncbi.nlm.nih.gov/books/NBK554746/
Motor neurone disease (MND) is a neurodegenerative condition that affects the brain and spinal cord. MND is characterised by the degeneration of primarily motor neurones, leading to muscle weakness. The presentation of the disease varies and can be as muscle weakness, wasting, cramps and stiffness of arms and/or legs; problems with speech and

https://www.nhs.uk/conditions/motor-neurone-disease/
Motor neurone disease (MND) is an uncommon condition that affects the brain and nerves. It causes weakness that gets worse over time. There's no cure for MND, but there are treatments to help reduce the impact it has on a person's daily life. Some people live with the condition for many years. MND can significantly shorten life expectancy and

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883149/
Introduction. Motor neurone disease (MND) is an adult-onset neurodegenerative disorder characterised by loss of upper motor neurons (UMNs, including the Betz cells of the motor cortex), and lower motor neuron (LMNs, anterior horn cells of the spinal cord and brainstem nuclei) (Figure 2a). 1 The term MND is largely synonymous with amyotrophic lateral sclerosis (ALS), reflecting the observation

https://www.medicalnewstoday.com/articles/164342
Early signs of motor neuron disease include weakness and slurred speech. Motor neurons are nerve cells that send electrical output signals to the muscles, affecting the muscles' ability to

https://www.cambridge.org/core/books/cambridge-handbook-of-psychology-health-and-medicine/motor-neurone-disease/6CA4589D87BA042ED9DF90496DA18795
Introduction. Motor Neurone Disease (MND), is a terminal, progressive neurodegenerative disease of the central nervous system. The most common form of MND is amyotrophic lateral sclerosis (ALS) involving both upper and lower motor neurones (UMNs, LMNs). Less common are primary lateral sclerosis (involving only UMNs) progressive muscular atrophy

https://www.healthdirect.gov.au/motor-neurone-disease-mnd
weakness in their legs, and a tendency to trip. weakness of their shoulder, making lifting difficult. cramps and muscles twitching. Later on, people with MND: become very weak and have little or no movement. have trouble talking, breathing and swallowing. A few people with MND develop a type of dementia.

https://www.intechopen.com/chapters/71937
1. Introduction. Motor neuron disease is composed of a group of rare neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), hereditary spastic paraplegia, primary lateral sclerosis, progressive muscular atrophy, pseudobulbar palsy, O'Sullivan-McLeod syndrome, and Madras motor neuron disease, which are fatal in 50% of affected people within 15

https://www.sciencedirect.com/topics/neuroscience/motor-neurone-disease
Introduction Definition. Motor neurone disease (MND) is characterized by the progressive deterioration of the anterior horn cells of the spinal cord and the corticospinal tracts, causing lower motor neurone lesions and upper motor neurone lesions respectively. Certain motor nuclei of the brainstem may also be affected, leading to bulbar paralysis.

https://www.open.edu/openlearncreate/mod/page/view.php?id=186465
What is Motor Neurone Disease (MND)? MND is a fatal, rapidly progressive terminal neurological disease that affects the brain and spinal cord. It attacks the nerves that control movement: people can still think and feel, but their muscles refuse to work. It can leave people locked in a failing body, unable to move, talk, and eventually, breathe.

https://accesspediatrics.mhmedical.com/content.aspx?bookid=3278&sectionid=272064028
Motor neuron diseases are a group of rare diseases affecting spinal motor neurons. They clinically present with progressive degenerative muscle weakness and wasting and lead to impairment in mobility, speech, swallowing, and breathing functions. Spinal muscular atrophy (SMA) is the leading cause for motor neuron disease in children.

https://www.mndassociation.org/support-and-information/information-resources/information-for-people-with-or-affected-by-mnd
An introduction to motor neurone disease (MND) A small booklet providing a short overview of MND. An audio version of this guide is also available. An easy read guide to motor neurone disease (MND) A guide to help you if you have reading difficulties or learning disabilities and have been diagnosed with MND.

https://www.uptodate.com/contents/society-guideline-links-motor-neuron-disease
Society guideline links: Motor neuron disease. Introduction. This topic includes links to society and government-sponsored guidelines from selected countries and regions around the world. We will update these links periodically; newer versions of some guidelines may be available on each society's website. Some societies may require users to log

https://oscestop.education/condition/motor-neurone-disease/
Introduction. Motor Neurone Disease (MND) is a progressive neurodegenerative disorder that affects motor neurones in the brain and spinal cord, leading to muscle weakness and wasting. The most common form of MND is Amyotrophic Lateral Sclerosis (ALS).

https://www.msn.com/en-gb/health/medical/everything-you-need-to-know-about-motor-neurone-disease/ar-AA1f6gGw
And the spectre of motor neurone disease (MND) was back in the news because of the untimely death at 57 of Bryan Randall, the photographer and long-time partner of Hollywood actress Sandra Bullock.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896226/
Introduction. Motor neuron disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disease with a median survival of 2-3 years. 1 Despite many promising preclinical studies and 125 phase II and phase III trials reported between 2008 and 2019, riluzole remains the only globally approved disease-modifying treatment, prolonging survival by an average

https://alsnewstoday.com/news/study-early-stage-als-fasudil-safe-preserves-motor-neurons/
Treatment with fasudil (RT1968), which Raya Therapeutic is testing for amyotrophic lateral sclerosis (ALS), was safe and outperformed a placebo at preserving motor neurons in adults with early-stage disease. That's according to data from ROCK-ALS (NCT03792490), an investigator-led Phase 2a trial

https://alsnewstoday.com/news/certain-spinal-cord-nerves-als-die-faster-than-others-study/
Using a mouse model of ALS caused by the SOD1 gene, the team of scientists combined detailed molecular tests with analyses based on artificial intelligence (AI) to get a better understanding of how each of these types of nerves is affected over the course of the disease's progression. "By using techniques that allow [us] to simultaneously study multiple cell types in spinal cord tissue

https://www.nature.com/articles/s41418-024-01334-1
A Motor coordination was assessed by rotarod test. The mean time spent on an accelerating rotarod was recorded for 2, 6, 8-month-old wild type (WT) and TRIM31 −/− mice. n = 10 mice per group.B

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068990/
Introduction. Motor neuron diseases (MNDs) are rare neurological disease groups of neurodegenerative disorders associated with the degeneration of motor neurons in the upper and lower extremities ().They include amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, hereditary spastic paraplegia, progressive muscular atrophy, spinal muscular atrophy, and pseudobulbar palsy ().

https://www.newshub.co.nz/home/new-zealand/2024/04/auckland-scientists-celebrate-major-motor-neurone-disease-breakthrough.html
"Being able to change the fate of a family, no longer passing down this gene and the risk of motor neurone disease. The whole room was in tears." About 400 Kiwis are today living with MND.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938673/
Introduction. Amyotrophic lateral sclerosis (ALS, the most common form of motor neurone disease, MND) is still a significantly life-shortening disorder for most cases, despite the benefits of specialised multidisciplinary care. 1 2 The diagnosis of MND is fundamentally clinical, supported by confirmatory electrophysiological findings and negative neuroimaging, and with generally no requirement

https://www.msn.com/en-gb/health/other/pendleside-hospice-ot-who-lost-her-dad-to-motor-neurone-disease-shining-a-light-on-the-condition/ar-BB1oRoJu
"Motor Neurone Disease is a cruel and relentless illness that can affect even the healthiest and fittest of people. Sadly, I lost my dad, John, to MND in 2015.