https://www.mayoclinic.org/drugs-supplements/methotrexate-injection-route-subcutaneous-route/proper-use/drg-20064776
Adults—At first, 10 to 25 milligrams (mg) once per week. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg once per week. Children—Use and dose must be determined by your doctor. For rheumatoid arthritis: Adults—At first, 7.5 milligrams (mg) once per week. Your doctor may adjust your dose as needed.

https://www.hopkinsarthritis.org/patient-corner/how-to-give-a-subcutaneous-injection/how-to-inject-methotrexate/
Drug Information Sheets. Methotrexate (Oral) Methotrexate (Injection) Risedronate (Actonel®) Sarilumab (Kevzara®) Sulfasalazine (Azulfidine®) Join Victoria Ruffing, RN, Nurse Manager at the Johns Hopkins Arthritis Center as she shares the proper way to inject Methotrexate.

https://www.youtube.com/watch?v=bXeJITbxRMo
Johns Hopkins Arthritis Center Nurse Manager Victoria Ruffing, RN shows the proper way to inject Methotrexate.

https://www.mayoclinic.org/drugs-supplements/methotrexate-injection-route-subcutaneous-route/description/drg-20064776
Methotrexate belongs to the group of medicines known as antineoplastics (cancer medicines). It blocks an enzyme that is needed by cells to live. This interferes with the growth of cancer cells, which are eventually destroyed by the body. For patients with arthritis or psoriasis, methotrexate may work by improving the immune system.

https://www.youtube.com/watch?v=gUDHG5RCnJQ
Learn how to use a pre-filled syringe to inject methotrexate, a medication for rheumatoid arthritis and other conditions, with this 3D video guide from Accord Healthcare. The video covers the

https://rheuminfo.com/docs/living-with-arthritis/Methotrexate-Injection-Sheet-RheumInfo.pdf
We would like to show you a description here but the site won't allow us.

https://abuhb.nhs.wales/files/patient-information-leaflets1/bones-and-joints-orthopaedics/home-administration-of-methotrexate-metoject-by-subcutaneous-injection-training-guide-for-patients-carers-pdf/
Methotrexate is one of a very few drugs that is only ever given once a week. It is important that you make a note of the date you give yourself the injection and chose a day when you have a good routine and can plan your once-a-week injection. Methotrexate is used to treat patients with specific types of inflammatory conditions.

https://www.hopkinsarthritis.org/patient-corner/drug-information/methotrexate-injection/
The usual dose is 7.5mg to 25mg per week. Methotrexate may be injected just under the skin or intramuscularly. Follow your rheumatologist's directions. Do not take more or less medicine than ordered. You should also take 1mg of folate (folic acid) each day. Your rheumatologist will prescribe the folic acid. This will help prevent side effects.

https://healthonline.washington.edu/sites/default/files/record_pdfs/Methotrexate-Injections.pdf
Prepare the methotrexate vial. • New vial: Pop off the plastic cap and throw it away. Clean the top of the vial with an alcohol swab. Swipe 3 times in the same direction. • Used vial: Before you draw the medicine, clean the top of the vial with an alcohol swab. Wipe 3 times in the same direction. Step 5. Step 6.

https://www.hopkinsrheumatology.org/rheumtv/how-to-inject-methotrexate/
Tagged With: Injection Education Johns Hopkins Rheumatology The Division of Rheumatology is a thriving clinical and academic center, which concentrates clinically on providing the most outstanding care to patients affected by a variety of common and uncommon rheumatic disorders.

https://www.rch.org.au/uploadedFiles/Main/Content/rheumatology/Methotrexate_-_how_to_give_injections_at_home.pdf
This is a step-by-step guide to giving subcutaneous (under the skin) injections of methotrexate for the management of your child's Juvenile Idiopathic Arthritis (JIA). This guide goes with an education program you will attend so that you can effectively, safely and confidently give methotrexate by injection at home. At each

https://rheumatology.org.au/For-Patients/Adult-Medication-Information/H-M/Self-Injecting-Methotrexate-for-the-Treatment-of-Arthritis
Using two fingers, pinch up a fold of skin and quickly insert the needle into the skin at a 90- degree angle. Insert the needle fully into the fold of skin. Push the plunger down completely to inject the liquid underneath your skin. Hold the skin securely until the injection is completed.

https://www.mayoclinic.org/drugs-supplements/methotrexate-injection-route-subcutaneous-route/precautions/drg-20064776
Methotrexate can lower the number of white blood cells in your blood, which increases the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection

https://my.clevelandclinic.org/health/drugs/19052-methotrexate-subcutaneous-injection
Methotrexate subcutaneous injections treat inflammatory conditions such as arthritis or psoriasis. They work by decreasing inflammation, which reduces pain. You give yourself the injection under your skin (subcutaneously). ... Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you

https://www.drugs.com/cdi/methotrexate-injection-subcutaneous.html
It is given as a shot into the fatty part of the skin on the top of the thigh or the belly area. If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot. ... How methotrexate injection (subcutaneous) is taken may change based on blood work results, side effects, and how well the drug is working.

https://rheumdoctor.com/how-to-inject-methotrexate/
Injecting the medicine. Pinch cleansed skin. Insert needle into the chosen area at a 45-degree angle. You may keep the skin pinched or let go of the skin. Push the plunger slowly to inject the medication. Once you have injected all of the medication, take the needle out of your skin.

https://www.uptodate.com/contents/use-of-methotrexate-in-the-treatment-of-rheumatoid-arthritis
Absorption and route of administration — Methotrexate (MTX) can be given by oral, subcutaneous, and intramuscular routes. Oral MTX is variably absorbed in the dose range used to treat rheumatoid arthritis (RA). Food does not affect MTX absorption to a significant degree . Thus, the medication may be given with a meal or in the fasting state.

https://www.drugs.com/cons/methotrexate-injection-subcutaneous.html
Methotrexate injection is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood, bone, lymph node, and uterus cancers. Methotrexate is also used to treat severe rheumatoid arthritis in adults and polyarticular juvenile idiopathic arthritis in children who had other treatments

https://www.drugs.com/mtm/methotrexate-injection.html
Methotrexate injection can cause serious or fatal side effects. Call your doctor at once if you have: sudden chest pain, wheezing, dry cough, feeling short of breath; swollen lymph glands, night sweats, weight loss; blisters or ulcers in your mouth, red or swollen gums, trouble swallowing, feeling very thirsty; blood in your urine or stools

https://arthritisaustralia.com.au/medication-search/self-injecting-methotrexate-for-the-treatment-of-arthritis/
Remove the protective cover from the methotrexate vial. If it has been used before rub the rubber top with an alcohol swab and allow 60 seconds to dry. Remove the cap of the needle and insert the needle through the rubber stopper of the vial. Push the plunger down to the end to push out any air from the syringe.

https://www.hopkinsarthritis.org/patient-corner/how-to-give-a-subcutaneous-injection/how-to-inject-rasuvo-methotrexate/
Sulfasalazine (Azulfidine®) Teriparatide (Forteo®) Tocilizumab (Actemra®) Tofacitinib (Xeljanz®/XeljanzXR®) Ustekinumab (Stelara®) Drug Information Sheet. Zolendronic Acid (Reclast®) Johns Hopkins Rheumatology. Johns Hopkins Lupus Center. Johns Hopkins Lyme Disease Research Center.

https://www.drugs.com/dosage/methotrexate.html
Usual Adult Dose for Acute Lymphoblastic Leukemia. The recommended dose varies from 10 to 5000 mg/m2 IV. Lower doses from 20 to 30 mg/m2/week IM can be given. Comments: When using high-dose injection of this drug regimen, adhere to the guidelines for high-dose methotrexate regimen and use leucovorin rescue as recommended.

https://www.bjchealth.com.au/connected-care/how-to-give-yourself-an-injection-of-subcutaneous-methotrexate
So, people who need to use Methotrexate via injection, under the skin (subcutaneously), will need to actually draw up the solution and then self-inject or they need to have a family member or health professional perform this. This can be very daunting. To help demystify this process, my friend and colleague, Dr Claire Barrett was involved in