https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423989/
Neurons are strongly connected with glial cells such as astrocytes, oligodendrocytes, and microglia throughout the brain tissue, and their dynamic interactions are critical for appropriate brain function [5, 16]. Every type of neurological disease is thought to include a glial component, which could be the primary or secondary cause . As a

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11011741/
1. Heterogeneity and Roles of Glial Cells in Neurodegenerative Pathologies of the Central Nervous System. When glial cells were first discovered, they were considered as "passive" cell populations with merely structural and supportive functions to sustain neuronal cells; however, as research in the field progressed, their heterogeneity and multifunctional properties progressively emerged.

https://www.nature.com/articles/s41583-020-0263-9
The subtypes of mature CNS glia are astrocytes, oligodendrocytes and microglia. As the brain's resident macrophages, microglia are classified as both glia and immune cells, making the immune

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644207/
Glial cells, as an important part of the nervous system, play a vital role in the occurrence of neurologic autoimmune disorders. Glial cells can be hyperactivated in the presence of autoantibodies or pathological changes, to influence neurologic autoimmune disorders. This review is mainly focused on the roles of glial cells in neurologic

https://www.nature.com/collections/ypjcncrzxn
Glial Cells in Health and Disease. Glial cells - traditionally thought as simply the "glue" of the nervous system - are increasingly recognized to play a critical role in the development

https://www.nature.com/articles/s41573-022-00390-x
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse functions in health and disease. Astrocyte dysfunction is found in numerous diseases, including

https://pubmed.ncbi.nlm.nih.gov/36046684/
Emerging data reveals that metabolic changes in glial cells can cause morphological and functional changes in conjunction with neuronal dysfunction under disease situations, highlighting the importance of neuron-glia interactions in the pathophysiology of neurological illnesses. In this context, it is required to improve our understanding of

https://pubmed.ncbi.nlm.nih.gov/38682185/
Innate lymphocytes, including microglial cells, astrocytes, and oligodendrocytes, play a crucial role in initiating neuroinflammatory reactions inside the central nervous system (CNS). The prime focus of this paper is on the involvement and interplay of neurons and glial cells in neurological disorders such as Alzheimer's Disease (AD), Autism

https://onlinelibrary.wiley.com/doi/10.1002/glia.23571
Glia is the top neurobiology journal for research into glial cells (also called gliocytes or neuroglia). Articles cover all aspects of glial cell biology in health and disease. ... Emerging evidence suggests that neuroinflammation is a key player in various neurological disorders, including neurodegenerative diseases and CNS injury

https://pubmed.ncbi.nlm.nih.gov/32272060/
Dopamine. Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion effic ….

https://journals.lww.com/nrronline/Fulltext/2022/03000/Therapeutic_potential_of_glial_cell_line_derived.1.aspx
ampal function leads to epilepsy and mood disorders. In the first section, we summarized the most salient knowledge on the role of glial cell-line-derived neurotrophic factor and its receptors focused on aging, cognition and neurodegenerative and hippocampal-related neurological diseases mentioned above. In the second section, we reviewed the therapeutic approaches, particularly gene therapy

https://www.frontiersin.org/research-topics/55365/glial-cells-in-health-and-disease-impacts-on-neural-circuits-and-plasticity/overview
Recently, it has been found that dysfunction of glial cells contributes to various neurological disorders and neurodegenerative diseases. Indeed, under pathological conditions, they become activated and trigger an insidious neuroinflammatory response, deterioration of metabolism, disruption of the blood-brain barrier, and impaired energy supply

https://ncbi.nlm.nih.gov/pmc/articles/PMC9405963/
In conclusion, m6A modification of glial cells is indispensable to the occurrence and development of neurological diseases, especially Alzheimer's disease and glioblastoma, although most research has focused on astrocytes, regarding the aspects of apoptosis or oxidative stress, and studies on schizophrenia or oligodendrocyte lineage cells are

https://www.imrpress.com/journal/FBL/29/4/10.31083/j.fbl2904142/htm
Innate lymphocytes, including microglial cells, astrocytes, and oligodendrocytes, play a crucial role in initiating neuroinflammatory reactions inside the central nervous system (CNS). The prime focus of this paper is on the involvement and interplay of neurons and glial cells in neurological disorders such as Alzheimer's Disease (AD), Autism Spectrum Disorder (ASD), epilepsy, and multiple

https://www.cell.com/fulltext/S0896-6273(08)00886-6
The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease. In this perspective, I review recent evidence that glial cells are critical participants in every major aspect of brain development, function, and disease. Far more active than once thought, glial cells powerfully control synapse formation, function, and blood flow.

https://www.sciencedirect.com/journal/brain-research/special-issue/10GMTTCXM80
Histological studies have demonstrated that in a range of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, ALS and MS the loss of CNS cells is associated with a glial cell response. For example, microglial cells undergo changes in morphology and astrocytes upregulate expression of intemediate filaments.

https://www.ninds.nih.gov/news-events/news/press-releases/scientists-identify-genes-linked-brain-cell-loss-als
About the National Institute of Neurological Disorders and Stroke (NINDS): NINDS is the nation's leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.. About the National Institute on Aging (NIA): NIA leads the U.S. federal

https://pubmed.ncbi.nlm.nih.gov/36009052/
They mainly include microglia, astrocytes, and the oligodendrocyte lineage cells. Moreover, glial cells may induce pathological changes, such as inflammatory responses, demyelination, and disruption of the blood-brain barrier, to regulate the occurrence and development of neurological diseases through various molecular mechanisms.

https://www.mdpi.com/2076-3425/14/7/633
The initiation of this condition encompasses a multitude of neuropathological mechanisms, such as ion channel malfunction, neuronal injury, inflammatory responses, changes in synaptic plasticity, and proliferation of glial cells. Despite extensive research, the exact causes of epilepsy are still unknown, presenting a significant challenge in

https://medicalxpress.com/news/2024-06-neuroscience-leverages-stem-cells-neurons.html
Using stem cells to advance understanding of neuron and synapse formation. Neuroscientists have traditionally used rodent systems to study these synaptic connections in the brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10080992/
This special issue of Frontiers in Cellular Neuroscience entitled "New insights into the role of neuroinflammation and glial cells in the development of neurological disorders" compile four articles, among which three are original research and one is a review, going from AD to ALS always highlighting the central role of glial cells in those

https://www.mcgill.ca/neuro/article/research/finding-master-switch-als
Half the battle in developing treatments for amyotrophic lateral sclerosis (ALS) is knowing what to target. Over 80 per cent of ALS cases are considered sporadic, meaning they have no known genetic cause and therefore no easy target for the development of effective treatments. Researchers know that a hallmark of all ALS is damage to the neuromuscular junction, severing the connection between

https://www.frontiersin.org/research-topics/21225/the-role-of-glial-cells-in-neurodegenerative-diseases
Research in neurodegenerative disease has traditionally focused on the study of neuronal populations and their associated phenotypes. However, the roles of both glia and the immune system are increasingly coming into the spotlight for several neurodegenerative diseases, with glia often at the core of disease onset and development. Microglia have been shown to be crucial for the pathophysiology

https://natsci.source.colostate.edu/neuroscience-research-leverages-stem-cells-to-understand-how-neurons-connect-and-communicate-in-the-brain/
Neuroscience research leverages stem cells to understand how neurons connect and communicate in the brain. ... Chanda said that several mutations in the Gephyrin protein have been associated with neurological disorders like epilepsy, which alters neuronal excitability in the human brain. That makes understanding its basic cellular function an

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243488/
Inflammasomes implicated in pathological conditions in glial cells. Inflammasomes can be activated in the CNS in response to different stressors. Inflammasome activation has been demonstrated in resident cell types of the CNS, including microglia, astrocytes, and oligodendrocytes. NLRP3, NLRCs and AIM are the inflammasomes located in glial

https://www.barnesandnoble.com/w/frontiers-in-clinical-drug-research-cns-and-neurological-disorders-zareen-amtul/1141395589
Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and

https://www.youtube.com/watch?v=PHkdaH-llFw
Just out 2hrs ago... "Gut Inflammation Linked to Alzheimer's Disease, Once Again"https://www.sciencealert.com/gut-inflammation-linked-to-alzheimers-disease-o