https://www.youtube.com/watch?v=lFO7pu0FhDE
Did you know that exercising for longevity is different from exercising for performance or for building muscles?Listen, if you exercise incorrectly, you may

https://www.nature.com/articles/s43587-021-00098-4
Together, numerous studies have provided evidence that (1) autophagy is compromised during the process of aging; (2) dysfunction of autophagy shortens lifespan in various experimental animal

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884674/
Metabolic integration of autophagy protein function. The activation of autophagy initiates an energetically-demanding process (Kaur and Debnath 2015) that is tightly regulated by the localization, accessibility, and proper modification of ATGs and associated proteins.In addition, many proteins that regulate autophagy undergo post-translational modifications (PTMs), including phosphorylation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674197/
Regular physical exercise can also cause many other effects that can affect positive aging and health; however, the molecular effects of exercise training on regulation of autophagy and processes involved in longevity promotion are not completely explained by the scientific society, and there is no general agreement on this issue (Andreotti et

https://podcasts.apple.com/us/podcast/autophagy-activation-why-most-people-exercise-wrong/id1500914743?i=1000584382539
Did you know that exercising for longevity is different from exercising for performance or for building muscles? Listen, if you exercise incorrectly, you may not gain the longevity benefits you think you're getting. It is possible to improve your performance and lose weight, without activation of

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538402/
The possibility that exercise-induced autophagy influences exercise performance is supported by the finding that BCL2 AAA mutated mice that are incapable of exercise-induced BCL2-Beclin-1 disassociation and autophagy activation have lower maximal exercise capacity than control mice (He et al. 2012). Of notice is that the lower maximal

https://www.nature.com/articles/s41580-018-0033-y
First, select tissues may require or benefit from autophagy activation in longevity paradigms, as tissue-specific overexpression of single autophagy genes is sufficient to extend lifespan.

https://www.nature.com/articles/s41556-018-0235-8
In this Review, Leidal et al. discuss the role and regulation of autophagy in aging. They cover how autophagy promotes longevity and restricts cellular damage, and discuss autophagy modulators for

https://pubmed.ncbi.nlm.nih.gov/31144030/
Currently, autophagy is viewed as a nexus of metabolic and proteostatic signalling that can determine key physiological decisions from cell fate to organismal lifespan. Here, we review the latest literature on the role of autophagy and lysosomes in stress response and longevity. We highlight the connections between autophagy and metabolic

https://www.frontiersin.org/articles/10.3389/fcell.2019.00183/full
Figure 1. The influence of exercise on cell signaling pathways that regulate autophagy. This figure shows how various pathways associated with longevity converge onto autophagy, and how exercise influences these pathways. Also indicated are the nodes upon which Metformin, Rapamycin, and Resveratrol are thought to act.

https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2021.803421/full
Regular physical exercise can also cause many other effects that can affect positive aging and health; however, the molecular effects of exercise training on regulation of autophagy and processes involved in longevity promotion are not completely explained by the scientific society, and there is no general agreement on this issue (Andreotti et

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912418/
1. Introduction. Regular physical exercise is a part of healthy lifestyle, with multiple cross-sectional studies consolidating reduced overall risk of cardiovascular diseases and cardiac events associated with habitual or leisure physical exercises [1,2].Ample evidence has indicated a much better survival rate following a cardiovascular event in those who are physically active in comparison

https://radiopublic.com/the-wellness-messiah-podcast-GAqBMp/s1!6e96b
It is possible to improve your performance and lose weight, without activation of the full power of exercise. Yes, that's right. To keep your body young, your muscles young, and your brain sharp, you must exercise with intention, with longevity in mind. This way has to do with a dormant mechanism in your body that you want to activate: autophagy.

https://www.tandfonline.com/doi/full/10.1080/27694127.2023.2190202
Despite extensive narrative reviews on exercise-induced autophagy in both animal and human studies 9, 26-29, the regulatory effects of physical exercise on autophagy in humans are still unclear. To the best of our knowledge, no systematic review or meta-analysis has examined the effects of physical exercise on autophagy in humans.

https://www.nature.com/articles/s41574-021-00551-9
Autophagy, ageing and lifespan. Autophagy is part of a convergent mechanism shared by various pathways involved in longevity and the regulation of lifespan. The expression of ATG-related proteins

https://tammy.ai/summaries/health/aging-and-gerontology/activate-autophagy-the-key-to
⏱️ Increasing time under stress without changing speed or adding resistance can increase intensity. 💼 Adding resistance, such as carrying a heavy bag, can increase intensity without changing speed or time under stress. 🏃‍♂️ A study of over 400,000 people found that vigorous exercise leads to the greatest longevity benefits and reduced mortality.

https://healthnews.com/longevity/biohacking/what-is-autophagy-and-how-can-it-promote-longevity/
Key takeaways: Autophagy is the process by which the body removes damaged cells. Autophagy plays a key role in fighting inflammation and aging-related diseases. Timed eating and exercise may help promote autophagy. It, however, slows down with aging, and your lifestyle choices may also inhibit and downregulate its activation.

https://link.springer.com/chapter/10.1007/978-981-15-0602-4_24
Autophagy is a conserved process that degrades intracellular components through lysosomes, thereby maintaining energy homeostasis and renewal of organelles. Mounting evidence indicates that autophagy plays a key role in aging and aging-related diseases. Enhanced autophagy can delay aging and prolong life span.

https://www.fightaging.org/archives/2019/12/the-benefits-of-calorie-restriction-most-likely-largely-result-from-increased-autophagy/
CR was shown to promote longevity or protect from hypoxia through a Sirtuin-1-dependent autophagy induction process. Another study also showed that life extension through methionine restriction required autophagy activation. Growing evidence supports the notion that autophagy has a substantial role in the beneficial effects of CR.

https://www.nature.com/articles/s41574-021-00551-9.pdf
Therefore, induction of adequate autophagy is a potential therapeu-tic target in the amelioration of age- related metabolic derangements. In this Review, we outline the mechanism of auto-phagy and

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950580/
1.3. Autophagy Is Regulated by Nutrient-Sensing Signaling. A variety of physiologically important stimuli induce the autophagy process, including organelle (ER, mitochondria) damage, hypoxia, and inflammation [].However, nutrients and energy stress are the most powerful regulators of the autophagy process [].Changes in the cellular energy status such as the withdrawal of nutrients, such as

https://open.spotify.com/episode/1w1lLi0uNNIqSohwaJ3Zzm
It is possible to improve your performance and lose weight, without activation of the full power of exercise. Yes, that's right. To keep your body young, your muscles young, and your brain sharp, you must exercise with intention, with longevity in mind. This way has to do with a dormant mechanism in your body that you want to activate: autophagy.

https://www.lifespan.io/news/long-term-resistance-exercise-increases-autophagy/
Exercise is believed to activate autophagy, particularly mitophagy, the removal of damaged mitochondria. This conclusion mostly comes from animal studies, whereas human data on exercise-induced autophagy is less consistent. In this systematic review, the researchers analyzed the results of 26 studies assessing the autophagic response to