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Making an old pain and fever medication
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2,176,645 Views ā€¢ May 20, 2017 ā€¢ Click to toggle off description
Today I will be making acetanilide, which was historically used as a pain reliever. It was discovered in 1886 and sold under the brand name Antifebrin by the company Kalle & Co. It has since been completely replaced by paracetamol/acetaminophen.

Video links:
ā€¢ NileBlue video: Ā Ā Ā ā€¢Ā TheĀ InterestingĀ HistoryĀ ofĀ Aniline-Ba...Ā Ā 
ā€¢ Doug's Lab Acetic anhydride (Part 1): Ā Ā Ā ā€¢Ā AceticĀ AnhydrideĀ PartĀ 1:Ā TheĀ KeteneĀ LampĀ Ā 
ā€¢ Doug's Lab Acetic anhydride (Part 2): Ā Ā Ā ā€¢Ā AceticĀ AnhydrideĀ PartĀ 2:Ā RunningĀ theĀ ...Ā Ā 
ā€¢ Making Aniline: Ā Ā Ā ā€¢Ā HowĀ toĀ makeĀ AnilineĀ Ā 

I followed the pathway sodium benzoate - benzene -- nitrobenzene -- aniline. All of those videos are on my channel

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Nile talks about lab safety: Ā Ā Ā ā€¢Ā ChemistryĀ isĀ dangerous.Ā Ā 
Metadata And Engagement

Views : 2,176,645
Genre: Science & Technology
Date of upload: May 20, 2017 ^^


Rating : 4.961 (461/46,662 LTDR)
RYD date created : 2022-04-09T13:23:14.204494Z
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YouTube Comments - 1,325 Comments

Top Comments of this video!! :3

@SimonBoshoff

6 years ago

Love your work! How about doing an "end of the world"-medicines series. You know.. how to make 5 or so of the most basic medicines.

7.2K |

@kalolord

6 years ago

Just a heads up for when you make para red: I've made it twice in the lab, and it is a VERY STRONG dye! It stains everything, expect yourself to be scrubbing your equipment for weeks after making it.

2.8K |

@KnolltopFarms

6 years ago

You know...half of the enjoyment I receive from your videos comes from the thought that you are really enjoying yourself on screen...or more precisely, on mic. You also have a great tone and syllabic tempo, so it adds to the easy enjoyment, thank you. Your average farmer.

1.1K |

@vanhetgoor

6 years ago

When I see you explaining and showing us how it is done, I get more respect for the chemists from one hundred years ago, who did all this work without modern equipment. Maybe they had a bunsen-burner, a thermometer and a scale. And a good set of brains of course!

1K |

@erikdimitrov8140

6 years ago

Finally some complicated organic synthesis again. I started getting a little bit bored from these extractions. Please do more videos like this one.

494 |

@Obi-Wan_Kenobi

2 years ago

I am very thankful for the modern medicine that exists today being both invented and easy to access. Thanks to them, my life is so much safer compared to the billions of humans who lived before me and I am incredibly grateful.

194 |

@cbjonsey5785

4 years ago

when i saw the title i was like ā€œohhhhh, heā€™s talking about heroineā€

303 |

@BrunoDantasS.5655

2 years ago

Me before knowing NileRed: "And i HATE Chemistry" Me after knowing NileRed: "And i LOVE Chemistry"

81 |

@elitearbor

6 years ago

Those are absolutely gorgeous crystals. Chemistry can be so aesthetically pleasing at times!

103 |

@MetallicAGirl14

2 years ago

Does anyone else have absolutely no knowledge in chemistry but love watching these videos? Nile could just make something that a child could make but Iā€™d be impressed šŸ˜‚

17 |

@Lostpanda123

6 years ago

Great video as always! Love that you take your time and go through the mechanisms!!

8 |

@carterplasek498

6 years ago

I love these organic synthesis videos, thank you for the great content!

33 |

@toxikspeaks689

3 years ago

Nilered, Thank you for the videos that you make, as someone who started chemistry about a year ago and has been teaching myself as of recent, these videos are very helpful. i find medicines in general to be incredibly interesting and i love how right off the bat i learned something i didnt know. I have some knowledge of old medicines but not near the knowledge it seems you have. Keep up the amazing work, you are an inspiration. don't worry though, im going back to school here soon to finish the degree.

57 |

@renanocsso

6 years ago

wow, next couple of months? This must be really a lot of work, and lots of studies. Great videos, you really teaches stuff. I can't wait to see the next one. Good work!!

17 |

@MLife1000

2 years ago

This channel is so interesting and the videos and explanations help make it easy to understand. Iā€™m glad I subscribed to this channel a few years ago.

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@RockyMountainBlades

2 years ago

Itā€™s just interesting how the first people to come up with involved reactions like this one were just like ā€œwoah i created some crazy chemical looking thing, i wonder if i can use it as a pain medication?ā€

24 |

@ColinRies

6 years ago

I think that Doug's Lab Acetic Anhydride method is pretty cool, but really dangerous and requires some specialized apparatus. The classic Acetyl Chloride (can be easily bought here) and Sodium Acetate method is much easier to do. Nice video anyway, I always wonder how you (and NurdRage, ChemPlayer, Doug's Lab,...) come up with such projects. Speaking of Para Red, got any plans to make actual Nile Red? I ask because Nile Red is a really cool dye with very interesting properties.

123 |

@rogvirstormblade9803

4 years ago

your videos are what made me want to follow a career in chemistry, just finished my first semester of college on the path to becoming a chemical engineer. thank you

79 |

@gavinli1368

2 years ago

Huh. Acetanilide. I vaguely recognize that from Dr. Stone. It was one of Senkuā€™s intermediary steps into making sulfanilamide to cure pneumonia in a stone age tech world.

19 |

@Hopee667

2 years ago

you are so amazingly brilliant your videos always blow my mind šŸ¤Æ thank you for doing everything safely too ā™„ļø

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