Progesterone prepares the lining of the uterus (endometrium) to allow a fertilized egg (embryo) to stick or implant. If a pregnancy does not take place, progesterone levels will fall and you will have your period.If an embryo implants into the lining of the uterus, the ovary will produce progesterone until eight weeks into the pregnancy. After that time, progesterone will be produced by the placenta throughout the rest of the pregnancy.

During an in vitro fertilization (IVF) cycle, medications are usually used to prevent you from releasing an egg early (premature ovulation). These medicines affect your progesterone levels.

Therefore, your doctor may prescribe a progesterone supplement to make up for this decrease in your ovary’s ability to make progesterone. That way, an embryo can implant and grow inside your uterus (womb).

Pregnancy rates in IVF cycles that use progesterone are much higher compared to cycles where no progesterone was used.
Doctors usually prescribe progesterone supplementation to start on the day the eggs are harvested. If a pregnancy takes place, the doctor may tell you to continue taking progesterone throughout the first trimester.
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