Scientists in China and the US have developed a groundbreaking plant-based nanoparticle treatment for glioblastoma, the fastest-growing and most aggressive type of brain cancer. Researchers from Renmin Hospital of Wuhan University and Yale University discovered that **bardoxolone methyl (BM)**—a naturally occurring phytochemical—can self-assemble into spindle-shaped nanoparticles, which effectively target tumor cells when injected into mice.

“These nanoparticles are designed to tackle two key challenges: efficiently penetrating the brain and killing glioblastoma cells,” the team wrote in their paper, published in the August edition of *Small Science*. The nanoparticles are incredibly small, with a diameter of just 50 to 80 nanometres and a length of around 170 nanometres—a nanometre being one-millionth of a millimeter. To put that in perspective, an average sheet of paper is about 100,000 nanometres thick.

Nanomedicine is rapidly emerging as a promising field in cancer treatment, and the BM nanoparticles show great potential as a safe and effective therapy for glioblastoma in particular. This cancer is not only one of the most common forms originating in the brain or spinal cord but also among the most aggressive, with patients typically diagnosed at stage four, the most advanced stage of cancer.

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