As researchers simulate early Earth conditions in an attempt to witness the synthesis of complex organic molecules like RNA or proteins from simpler compounds, they often encounter a hurdle: Along with the desired biological monomers, the reactions produce a sticky, inert tar - a mishmash of organic materials that are not biologically useful and gum up further chemical reactions.

Here's how scientists are working on the puzzle:

1. Mineral Assistance: In nature, minerals like clays could have acted as catalysts, promoting the right chemical reactions and preventing unwanted ones that lead to tar. Laboratory experiments have shown that minerals can, in deed, stabilize necessary molecules and encourage their formation, mimicking natural processes that could have occurred on early Earth.
2. Creating Compartments: By forming vesicles and micelles, which are like tiny bubbles or pockets, scientists simulate how early cell membranes might have worked. These structures can isolate important molecules, protecting them from the chaotic external environment and helping them to react correctly. Experiments confirm that these compartments can form under prebiotic conditions, and can act (minimally), to sort compounds out of tar-like mixtures.
3. Cyclical Reaction Processes: Nick Hud's research into depsipeptides provides a compelling example of how cyclic environmental conditions, similar to day/night cycles, could influence the formation of complex organic molecules. By simulating these cycles in the lab, Hud explores how alternating periods of wet and dry conditions could facilitate the polymerization of depsipeptides, which are chains consisting of both amino acids and hydroxy acids. This approach highlights the potential for natural rhythms to promote the chemical evolution necessary for life's origins. Hud's work demonstrates that depsipeptides can form under such cyclic conditions, offering insights into how early life might have developed molecular complexity through natural processes.

These laboratory strategies are not about artificially creating life, but rather about understanding and eventually replicating the natural conditions that might have allowed life to form spontaneously on the primitive Earth. By simulating these environments, scientists gain insights into what natural paths could have led to the complex chemistry of life amid a world prone to producing tar.