Auvelity is an NMDA Antagonist. It works differently than other antidepressants.

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Auvelity is an NMDA Antagonist. It works differently than other antidepressants.

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Rittenhouse Psychiatric Associates

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2,548 Views • Aug 23, 2023 • Click to toggle off description

Auvelity (dextromethorphan + bupropion) is an NMDA antagonist, which increases glutamate levels. This is different than our other antidepressants, so if someone has failed multiple medication trials for depression, this may be a good option. We've seen patients who had very treatment resistant depression, respond well to this medication.

Dr. Pagnani is the Medical Director of Rittenhouse Psychiatric Associates in Philadelphia, an Instructor at The Johns Hopkins Hospital and he supervises psychiatric residents at Jefferson Hospital. www.RittenhousePA.com or visit @RittenhousePsych for 100's of educational mental health videos.

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