Filters
Upload date
Duration
Sort By

Videos
Watch :3 15:42
I Asked 10 Isaac Youtubers To Buff The WORST Items!
284K views • 4 months ago SlayXc2
Watch :3 40:46
MOST FUN RUN OF THE YEAR! (so far) #isaac - #1062
63K views • 9 months ago Sinvicta
Watch :3 00:52
5 MORE Beginner Tips for The binding of Isaac #gaming #isaac #bindingofisaac #tips #beginners
559K views • 1 year ago Matt Murderous
Watch :3 04:01
Hollyn - Isaac (Official Music Video)
671K views • 6 years ago Hollyn
Watch :3 01:01
The NEW Mars is BROKEN #repentance #satisfying #isaac
97K views • 2 days ago Vicfis
Watch :3 00:49
How BOSS PROGRESSION in The Binding of Isaac works - Part 1
925K views • 6 months ago Bambochutafreak
Watch :3 10:29
What Isaac Did To His Teacher In Class🤣🤣
472K views • 4 months ago Kat The Comedian malome kat
Watch :3 04:51
Isaac Have Anger Issues 🤣🤣🤣
83K views • 11 months ago Kat The Comedian malome kat
Watch :3 00:14
When it will be fixed... #isaac #tboirepentance
771 views • 1 day ago postmortemrigidity
Watch :3 02:29
The CREEPIEST Isaac Boss EVER! Cacophobia (Fiend Folio)
2.5M views • 2 years ago SlayXc2
Watch :3 01:00
5 EASY ways to get infinite money in Greed Mode #gaming #isaac #guide
760K views • 5 months ago Vicfis
Watch :3 00:58
The LOST guide for The Binding of Isaac Repentance! #gaming #isaac #deathcertificates
514K views • 5 months ago Vicfis
Watch :3 00:57
How BOSS PROGRESSION in The Binding of Isaac works - Part 2
660K views • 6 months ago Bambochutafreak
Watch :3 24:19
Trying the original Isaac game
333K views • 2 years ago Killysunt DLC
Watch :3 00:43
Turn quality-0 items to quality-4! #repentance #isaac #tips
1.4M views • 1 year ago Taz
Watch :3 09:14
Isaac In Class.. 🙆‍♂️🤣🤣🤣 Trouble boy
459K views • 6 months ago Kat The Comedian malome kat
Watch :3 00:19
TIPS FOR BEGINNERS OF BINDING OF ISAAC
786K views • 8 months ago Kayhos
Watch :3 01:00
ISAAC REVERSE CARDS #short #thebindingofisaac #tboi #isaac #foryou #mod #game #wildcard
116K views • 9 months ago Planock
Watch :3 01:00
Every item buff in Repentance Plus! #isaac #gaming
315K views • 3 months ago Vicfis
Watch :3 00:58
AZAZEL BUILD #short #shorts #thebindingofisaac #tboi #isaac #foryou #game #wildcard
805K views • 9 months ago Planock
Watch :3 26:22
Isaac Speedruns are INSANE
74K views • 4 weeks ago Another Matt Playing Isaac
Watch :3 00:43
HOW TO REACH BASEMENT FLOOR 9999999 #bindingofisaac #isaac #repentance
195K views • 1 year ago Chunobi
Watch :3 00:48
Best Synergies In Binding Of Isaac For Once
387K views • 4 weeks ago Kayhos
Watch :3 10:03
Is isaac Dumb or Troublemaker?🤣🤣
20K views • 1 day ago Kat The Comedian malome kat
Watch :3 00:59
Isaac is FED UP With Humans | #youtubeshorts #shorts #castlevania #isaac #dracula #netflix #anime
529K views • 7 months ago Cartoon Addict
Watch :3 01:00
How to unlock TARNISHED Maggy in the Binding of Isaac Epiphany Mod! #thebindingofisaac #isaac
162K views • 5 months ago Vicfis
Watch :3 00:12
The Average Isaac Player #gaming #bindingofisaac #isaac #shorts
84K views • 6 months ago Another Matt Playing Isaac
Watch :3 01:06:48
Isaac CHARACTERS Tips & Tricks
273K views • 9 months ago Another Matt Playing Isaac
Watch :3 00:10
The truth about playing with Judas in the binding of isaac
1M views • 8 months ago Kayhos
Watch :3 00:32
POPULAR MODS FOR THE BINDING OF ISAAC!!
318K views • 7 months ago 🜏El Mapache of Isaac🜏
Watch :3 00:38
Isaac Receives A Gift 🎁 | Castlevania 🏯 | Isaac
721K views • 1 year ago Purrfect Bella
Watch :3 01:23
Top 5 Duct Tape Synergies In Isaac! #tboi #isaac
300K views • 3 weeks ago SlayXc2
Watch :3 00:24
Easy ways to BREAK the Binding of Isaac - Part 1
81K views • 6 months ago Bambochutafreak
Watch :3 00:23
Sacrifice rooms are the best! - The Binding Of Isaac
102K views • 11 months ago Kayhos
Watch :3 20:30
The Ultimate Guide to the Binding of Isaac: Path to Dead God
1.3M views • 3 years ago Priets
Watch :3 02:40
ISAAC - MANEW (official audio) | “ማነው”
12K views • 9 months ago Isaac Addisu