Meryem Uzerli was born and raised in Kassel, Germany. She made her acting debut with minor parts in German productions. She later made minor appearances in the television series Notruf Hafenkante (2010) and Ein Fall für zwei (2010). Uzerli is also known for her roles in German films like Journey of No Return (2010) and Jetzt aber Ballett (2010). At the end of 2010, she was chosen by Meral Okay for her first leading role in the Turkish TV series Muhteşem Yüzyıl (2011–2013). In addition to her acting career, Uzerli has appeared in many advertising films and is the face of numerous brands. In 2012, she was chosen as the Woman of the Year by GQ Turkey. She won total 23 awards for her role as Hurrem Sultan in Muhtesem Yuzyil. And she is one of the most famous Turkish actress.